舘野 浩章 公式サイト
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Project

細胞 Single cell

Press release

  1. 膵がんの免疫回避能力を糖鎖でコントロール
  2. 糖鎖で見分けるiPS細胞の分化のばらつき
  3. １細胞ごとの糖鎖と遺伝子の情報、１万個分を一斉解読
  4. 個々の細胞の糖鎖をプロファイリングする技術を開発

Notable publications

  1. GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer. Anh DXT, Keisham S, Burramsetty A, Oinam L, Kumano K, Kuno A, Shimomura O, Oda T, Tateno H. Adv Sci (Weinh). 2026 Mar;13(14):e14735
  2. Single-cell glycome and transcriptome profiling uncovers the glycan signature of each cell subpopulation of human iPSC-derived neuronsOdaka H, Tateno H. Stem Cell Reports. 2025 Oct 14;20(10):102631
  3. Emerging technologies for single-cell glycomicsKeisham S, Tateno H. BBA Adv. 2024 Nov 26;6:100125
  4. Droplet-Based Glycan and RNA Sequencing for Profiling the Distinct Cellular Glyco-States in Single Cells. Keisham S, Saito S, Kowashi S, Tateno H. Small Methods. 2024 Jan 2:e2301338
  5. Glycan profiling of the gut microbiota by Glycan-seq. Oinam L, Minoshima F, Tateno H. ISME COMMUN. 2, 1 (2022)
  6. Integrated analysis of glycan and RNA in single cells. Minoshima F, Ozaki H, Odaka H, Tateno H. iScience. 2021 Jul 17;24(8):102882

ウイルス Virus

Press release

  1. 新型コロナウイルスの感染を阻害するペプチドを発見

Notable publications

  1. HIV-induced sialoglycans on infected CD4+ T cells promote immune evasion from myeloid cell-mediated killing. Singh S, Islam SMS, Liu R, Adeniji OS, Simons LM, Saini P, Tateno H, Danesh A, Denton PW, Giron LB, Jones RB, Hultquist JF, Xiao H, Abdel-Mohsen M.Nat Commun. 2025 Dec 13;17(1):18
  2. A glycosaminoglycan microarray identifies the binding of SARS-CoV-2 spike protein to chondroitin sulfate E. Watanabe T, Takeda K, Hiemori K, Minamisawa T, Tateno H. FEBS Lett. 2021 Aug 10:10.1002/1873-3468.14173
  3. Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection. Giron LB, Tanes CE, Schleimann MH, Engen PA, Mattei LM, Anzurez A, Damra M, Zhang H, Bittinger K, Bushman F, Kossenkov A, Denton PW, Tateno H, Keshavarzian A, Landay AL, Abdel-Mohsen M. Mucosal Immunol. 2020 Sep;13(5):753-766
  4. Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint. Giron LB, Papasavvas E, Azzoni L, Yin X, Anzurez A, Damra M, Mounzer K, Kostman JR, Sanne I, Firnhaber CS, Tateno H, Liu Q, Montaner LJ, Abdel-Mohsen M. AIDS. 2020 Apr 1;34(5):681-686
  5. Interferon-α alters host glycosylation machinery during treated HIV infection. Giron LB, Colomb F, Papasavvas E, Azzoni L, Yin X, Fair M, Anzurez A, Damra M, Mounzer K, Kostman JR, Tebas P, O'Doherty U, Tateno H, Liu Q, Betts MR, Montaner LJ, Abdel-Mohsen M. EBioMedicine. 2020 Sep;59:102945
  6. Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy. Colomb F, Giron LB, Kuri-Cervantes L, Adeniji OS, Ma T, Dweep H, Battivelli E, Verdin E, Palmer CS, Tateno H, Kossenkov AV, Roan NR, Betts MR, Abdel-Mohsen M. Cell Rep. 2020 Aug 4;32(5):107991

エクソソーム Exosome

Press release

  1. 表層糖鎖パターン解析による細胞外小胞の多様性評価

Notable publications

  1. Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications. Asako Shimoda A, Miura R, Tateno H, Seo N, Shiku H, Sawada S, Sasaki Y, Akiyoshi K. Small Methods. 2022 Feb;6(2):e2100785.
  2. Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays. Odaka H, Hiemori K, Shimoda A, Akiyoshi K, Tateno H. FEBS Open Bio. 2021 Mar;11(3):741-752
  3. Glycome analysis of extracellular vesicles derived from human induced pluripotent stem cells using lectin microarray. Saito S, Hiemori K, Kiyoi K, Tateno H. Sci Rep. 2018 Mar 5;8(1):3997.

がん Cancer

Press release

  1. 膵がんの免疫回避能力を糖鎖でコントロール
  2. 膵がん細胞表面の糖鎖をレクチン融合薬で狙い撃ち- ポスト抗体医薬としての新規抗がん治療法開発へ -

Notable publications

  1. Identification of CLEC10A as a human lectin for pancreatic ductal adenocarcinoma. Tsukamoto S, Tateno H, Shimomura O, Yamamoto K, Saito S, Murakami J, Nakahashi H, Miyazaki Y, Enomoto T, Oda T. Sci Rep. 2025 May 21;15(1):17652
  2. Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target. Arai J, Hayakawa Y, Tateno H, Murakami K, Hayashi T, Hata M, Matsushita Y, Kinoshita H, Abe S, Kurokawa K, Oya Y, Tsuboi M, Ihara S, Niikura R, Suzuki N, Iwata Y, Shiokawa T, Shiomi C, Uekura C, Yamamoto K, Fujiwara H, Kawamura S, Nakagawa H, Mizuno S, Kudo T, Takahashi S, Ushiku T, Hirata Y, Fujii C, Nakayama J, Shibata S, Woods S, Worthley DL, Hatakeyama M, Wang TC, Fujishiro M. Gastroenterology. 2024 Aug;167(3):505-521.e19. doi: 10.1053/j.gastro.2024.03.037.
  3. Lectin-based phototherapy targeting cell surface glycans for pancreatic cancer. Kuroda Y, Oda T, Shimomura O, Hashimoto S, Akashi Y, Miyazaki Y, Furuya K, Furuta T, Nakahashi H, Louphrasitthiphol P, Mathis BJ, Nakajima T, Tateno H. Int J Cancer. 2023 Apr 1;152(7):1425-1437
  4. rBC2LCN-reactive SERPINA3 is a glycobiomarker candidate for pancreatic ductal adenocarcinoma. Mawaribuchi S, Shimomura O, Oda T, Hiemori K, Shimizu K, Yamase K, Date M, Tateno H. Glycobiology. 2023 May 17;33(4):342-352
  5. Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: 18 F-labeled rBC2LCN lectin. Kuroda Y, Oda T, Shimomura O, Louphrasitthiphol P, Mathis BJ, Tateno H, Hatano K. Cancer Sci. 2023 Aug;114(8):3364-3373
  6. Carcinoembryonic antigen as a specific glycoprotein ligand of rBC2LCN lectin on pancreatic ductal adenocarcinoma cells. Furuta T, Oda T, Kiyoi K, Ozawa Y, Kimura S, Kurimori K, Miyazaki Y, Yu Y, Furuya K, Akashi Y, Shimomura O, Tateno H. Cancer Sci. 2021 Jun 11
  7. A Novel Therapeutic Strategy for Pancreatic Cancer: Targeting Cell Surface Glycan Using rBC2LC-N Lectin-Drug Conjugate (LDC). Shimomura O, Oda T, Tateno H, Ozawa Y, Kimura S, Sakashita S, Noguchi M, Hirabayashi J, Asashima M, Ohkohchi N.Mol Cancer Ther. 2018 Jan;17(1):183-195.

微生物 Bacteria

Notable publications

  1. Gut mucin fucosylation dictates the entry of botulinum toxin complexes. Amatsu S, Matsumura T, Morimoto C, Keisham S, Goto Y, Kohda T, Hirabayashi J, Kitadokoro K, Katayama T, Kiyono H, Tateno H, Zuka M, Fujinaga Y. Nat Commun. 2025 Nov 25;16(1):10442
  2. Glycophenotyping of mutants of Lacticaseibacillus paracasei by lectin microarraySuzuki E, Serata M, Sako T, Sato S, Iino T, Tateno H, Hirabayashi J. Appl Environ Microbiol. 2025 Aug 20;91(8):e0170724
  3. Glycan profiling of the gut microbiota by Glycan-seq. Oinam L, Minoshima F, Tateno H. ISME COMMUN. 2, 1 (2022). doi: https://doi.org/10.1038/s43705-021-00084-2.
  4. Lectin microarray reveals binding profiles of Lactobacillus casei strains in a comprehensive analysis of bacterial cell wall polysaccharides. Yasuda E, Tateno H, Hirabayashi J, Iino T, Sako T. Appl Environ Microbiol. 2011 Jul;77(13):4539-46

神経変性・精神疾患
Neurodegenerative / mental disorder

Press release

  1. 精神的ストレスは腸管上皮の糖鎖構造を変化させる - マウスで確認、腸内細菌－腸－脳相関のメカニズムの解明に活用 -

Notable publications

  1. Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays. Odaka H, Hiemori K, Shimoda A, Akiyoshi K, Tateno H. FEBS Open Bio. 2021 Mar;11(3):741-752
  2. Reduced fucosylation in the distal intestinal epithelium of mice subjected to chronic social defeat stress. Omata Y, Aoki R, Aoki-Yoshida A, Hiemori K, Toyoda A, Tateno H, Suzuki C, Takayama Y. Sci Rep. 2018 Sep 4;8(1):13199.

幹細胞 Stem cells

Press release

  1. 糖鎖で見分けるiPS細胞の分化のばらつき
  2.  加齢に伴う皮膚幹細胞の糖鎖変化の解析に成功
  3. ヒト間葉系幹細胞の分化する能力を評価できる技術を開発 - 簡便・迅速な評価で再生医療への実用化に貢献 -
  4. 移植用細胞から腫瘍を引き起こすヒトiPS/ES細胞を除く技術を開発 - 再生医療で腫瘍が発生するリスクを低減させることが可能に -
  5. 再生医療に用いる細胞の安全性を培養液で検査することが可能に
  6. ヒトiPS細胞を生きたまま可視化できるプローブを開発
  7. 糖鎖の迅速プロファイリング技術でiPS細胞を精密評価

Notable publications

  1. Single-cell glycome and transcriptome profiling uncovers the glycan signature of each cell subpopulation of human iPSC-derived neuronsOdaka H, Tateno H. Stem Cell Reports. 2025 Oct 14;20(10):102631
  2. Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging. Oinam L, Changarathil G, Raja E, Ngo YX, Tateno H, Sada A, Yanagisawa H. Aging Cell. 2020 Jul 18:e13190
  3. Elimination of cells deviated from human induced pluripotent stem cells with a photoactivatable IR700-labelled antibody. Watanabe T, Tateno H. Biochem Biophys Res Commun. 2021 May 21;554:13-18
  4. Monoclonal antibodies specific for podocalyxin expressed on human induced pluripotent stem cells. Watanabe T, Kakuta J, Saito S, Hasehira K, Kiyoi K, Imai T, Tateno H Biochem Biophys Res Commun. 2020 Nov 19;532(4):647-654
  5. Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging. Oinam L, Changarathil G, Raja E, Ngo YX, Tateno H, Sada A, Yanagisawa H. Aging Cell. 2020 Jul 18:e13190
  6. Structural and quantitative evidence of α2-6-sialylated N-glycans as markers of the differentiation potential of human mesenchymal stem cells
  7. Elimination of tumorigenic human pluripotent stem cells by a recombinant lectin-toxin fusion protein. *Tateno H(CA), Onuma Y, Ito Y, Minoshima F, Saito S, Shimizu M, Aiki Y, Asashima M, Hirabayashi J. Stem Cell Reports. 2015 May 12;4(5):811-20.
  8. A medium hyperglycosylated podocalyxin enables noninvasive and quantitative detection of tumorigenic human pluripotent stem cells. *Tateno H(CA), Onuma Y, Ito Y, Hiemori K, Aiki Y, Shimizu M, Higuchi K, Fukuda M, Warashina M, Honda S, Asashima M, Hirabayashi J. Sci Rep. 2014 Feb 12;4:4069
  9. Structural and quantitative evidence for dynamic glycome shift on production of induced pluripotent stem cells. Hasehira K, Tateno H, Onuma Y, Ito Y, Asashima M, Hirabayashi J. Mol Cell Proteomics. 2012 Dec;11(12):1913-23
  10. Glycome diagnosis of human induced pluripotent stem cells using lectin microarray. *Tateno H, Toyota M, Saito S, Onuma Y, Ito Y, Hiemori K, Fukumura M, Matsushima A, Nakanishi M, Ohnuma K, Akutsu H, Umezawa A, Horimoto K, Hirabayashi J, Asashima M. J Biol Chem. 2011 Jun 10;286(23):20345-53

レクチン Lectins

Press release

  1. ダニによるアトピー性皮膚炎を抑制する分子の発見

Notable publications

  1. Self-Assembling Lectin Nano-Block Oligomers Enhance Binding Avidity to Glycans. Irumagawa S, Hiemori K, Saito S, Tateno H, Arai R. Int J Mol Sci. 2022 Jan 8;23(2):676. doi: 10.3390/ijms23020676.
  2. Structural basis for specific recognition of core fucosylation in N-glycans by Pholiota squarrosa lectin (PhoSL). Yamasaki K, Kubota T, Yamasaki T, Nagashima I, Shimizu H, Terada RI, Nishigami H, Kang J, Tateno M, Tateno H. Glycobiology. 2019 Jul 1;29(7):576-587
  3. Engineering of recombinant Wisteria floribunda agglutinin specifically binding to GalNAcβ1,4GlcNAc (LacdiNAc). Sato T, Tateno H, Kaji H, Chiba Y, Kubota T, Hirabayashi J, Narimatsu H. Glycobiology. 2017 May 26
  4. Engineering of a 3'-sulpho-Galβ1-4GlcNAc-specific probe by a single amino acid substitution of a fungal galectin. Hu D, Huang H, Tateno H, Nakakita S, Sato T, Narimatsu H, Yao X, Hirabayashi J. J Biochem. 2015 Apr;157(4):197-200
  5. Mammalian Cell Surface Display as a Novel Method for Developing Engineered Lectins with Novel Characteristics. Soga K, Abo H, Qin SY, Kyoutou T, Hiemori K, Tateno H, Matsumoto N, Hirabayashi J, Yamamoto K. Biomolecules. 2015 Jul 20;5(3):1540-62
  6. Tailoring GalNAcα1-3Galβ-specific lectins from a multi-specific fungal galectin: dramatic change of carbohydrate specificity by a single amino-acid substitution. Hu D, Tateno H, Sato T, Narimatsu H, Hirabayashi J. Biochem J. 2013 Jul 15;453(2):261-70
  7. Engineering of the glycan-binding specificity of Agrocybe cylindracea galectin towards α(2,3)-linked sialic acid by saturation mutagenesis. Imamura K, Takeuchi H, Yabe R, Tateno H, Hirabayashi J. J Biochem. 2011 Nov;150(5):545-52
  8. Directed evolution of lectins with sugar-binding specificity for 6-sulfo-galactose. Hu D, Tateno H, Kuno A, Yabe R, Hirabayashi J. J Biol Chem. 2012 Jun 8;287(24):20313-20.