Tsurugizawa's lab


Research map
Google Scholar

*corresponding author


Pham C, Komaki Y, Deàs-Just A, Le Gac B, Mouffle C, Franco C, Vialou V,Tsurugizawa T*, Cauli B*, Li D*.

Astrocyte aquaporin mediates a tonic water efflux maintaining brain homeostasis

eLife, 2024 Reviewed preprint

Satake T, Taki A, Ouchi K, Kasahara K, Tsurugizawa T*.

Increased Functional Connectivity Following Ingestion of Dried Bonito Soup

Frontiers in Nutrition, 2024 Accepted

Satake T, Taki A, Kasahara K, Yoshimaru D, Tsurugizawa T*.

Comparison of local activation, functional connectivity, and structural connectivity in the N-back Task

Frontiers in Neuroscience, 2024 March | https://doi.org/10.3389/fnins.2024.1337976.


Hikishima K, Tsurugizawa T, Kasahara K, Hayashi R, Takagi R, Yoshinaka K, Nitta N.

Functional ultrasound reveals effects of MRI acoustic noise on brain function

NeuroImage. 2023 Nov 1:281:120382. doi: 10.1016/j.neuroimage.2023.120382.

Tsurugizawa T*, Taki A, Zalesky A, Kasahara K.

Increased interhemispheric functional connectivity during non-dominant hand movement in right-handed subjects

iScience. 2023 Aug 19;26(9):107592. doi: 10.1016/j.isci.2023.107592. eCollection 2023 Sep 15.

Tsurugizawa T*, Kumamoto T, Yoshioka Y.

Micro-magnetic resonance imaging of ex vivo mouse embryos with potato starch suspension

STAR Protocols. 2023 Jul 29;4(3):102483. doi: 10.1016/j.xpro.2023.102483.

Hikishima K, Tsurugizawa T, Kasahara K, Takagi R, Yoshinaka K, Nitta N.

Brain-wide mapping of resting-state networks in mice using high-frame rate functional ultrasound

NeuroImage. 2023 Jul 26;120297. doi: 10.1016/j.neuroimage.2023.120297.

Murakami T, Ishida T, Tanaka S, Nakayama J, Tsurugizawa T, Takahashi Y, Kato F, Kawamata M.

Inflammation and subsequent nociceptor sensitization in the bone marrow are involved in an animal model of osteoarthritis pain

Life Sciences. 2023 Apr 28;121736. doi: 10.1016/j.lfs.2023.121736.


Tsurugizawa T* Kumamoto T, Yoshioka Y*.

Utilization of potato starch suspension for MR-microimaging in ex vivo mouse embryos

iScience. 2022 Nov 30, doi:10.1016/j.isci.2022.105694.


Tsurugizawa T*, Daisuke Yoshimaru.

Impact of anesthesia on static and dynamic functional connectivity in mice

NeuroImage. 2021 Jul 19. doi: 10.1016/j.neuroimage.2021.118413.

Tokunaga R, Paquette T, Tsurugizawa T, Leblond H, Piché M.

Fasting prevents medetomidine-induced hyperglycaemia and alterations of neurovascular coupling in the somatosensory cortex of the rat during noxious stimulation

European Journal of Neuroscience. 2021 Jun 16. doi: 10.1111/ejn.15350.

Tsurugizawa T*, Tamada K, Debacker C, ZaleskyA and Takumi T

Cranioplastic Surgery and Acclimation Training for Awake Mouse fMRI

Bio-Protocol. 2020 Apr 5;11(7). doi: 10.21769/BioProtoc.3972.


Nakamura Y, Nakamura Y, Pelosi A, Djemai B, Debacker C, Hervé D, Girault JA*, Tsurugizawa T*

fMRI detects bilateral brain network activation following unilateral chemogenetic activation of direct striatal projection neurons

NeuroImage. 2020 Oct 15;220:117079. doi: 10.1016/j.neuroimage.2020.117079.

Komaki Y, Debacker C, Djemai B, Ciobanu L, Tsurugizawa T, Le Bihan D

Differential Effects of aquaporin-4 Channel Inhibition on BOLD fMRI and Diffusion fMRI Responses in Mouse Visual Cortex

PLoS One. 2020 May 21;15(5):e0228759. doi: 10.1371/journal.pone.0228759. eCollection 2020.

Debacker C, Djemai B, Ciobanu L, Tsurugizawa T*, Le Bihan D*

Diffusion MRI Reveals in Vivo and Non-Invasively Changes in Astrocyte Function Induced by an aquaporin-4 Inhibitor

PLoS One. 2020 May 15;15(5):e0229702. doi: 10.1371/journal.pone.0229702. eCollection 2020.

Tsurugizawa T*, Tamada K, Ono N, Karakawa S, Kodama Y, Debacker C, Hata J, Okano H, Kitamura A, Zalesky A, Takumi T*

Awake functional MRI detects neural circuit dysfunction in a mouse model of autism

Science Advances. 2020 Feb 5;6(6):eaav4520. doi: 10.1126/sciadv.aav4520.


Droguerre M, Tsurugizawa T#, Duchêne A, Portal B, Guiard BP, Déglon N, Rouach N, Hamon M, Mouthon F, Ciobanu L, Charvériat M

A New Tool for In Vivo Study of Astrocyte Connexin 43 in Brain

Scientific Reports. 2019 Dec 4;9(1):18292. doi: 10.1038/s41598-019-54858-9.

#Equally conntributed

Arimura D, Shinohara K, Takahashi Y, Sugimura YK, Sugimoto M, Tsurugizawa T, Marumo K and Kato F

Primary role of the amygdala in spontaneous inflammatory pain-associated activation of pain networks – a chemogenetic manganese-enhanced MRI approach

Frontiers in Neural Circuits, 2019. doi: 10.3389/fncir.2019.00058.

Boido D, Rungta RL, Osmanski BF, Roche M, Tsurugizawa T, Le Bihan D, Ciobanu L, Charpak S

Mesoscopic and microscopic imaging of sensory responses in the same animal

Nature Communications. 2019 Mar 7;10(1):1110. doi: 10.1038/s41467-019-09082-4.

Abe Y, Tsurugizawa T, Le Bihan D, Ciobanu L

Spatial contribution of hippocampal BOLD activation in high-resolution fMRI

Scientific Reports. 2019 Feb 28;9(1):3152. doi: 10.1038/s41598-019-39614-3.

Tsurugizawa T*, Djemai B, Zalesky A

The impact of fasting on resting state brain networks in mice

Scientific Reports. 2019 Feb 27;9(1):2976. doi: 10.1038/s41598-019-39851-6.

Kitamura A, Hojo Y, Ikeda M, Karakawa S, Kuwahara T, Kim J, Soma M, Kawato S, Tsurugizawa T*

Ingested d-Aspartate Facilitates the Functional Connectivity and Modifies Dendritic Spine Morphology in Rat Hippocampus

Cerebral Cortex. 2019 Jun 1;29(6):2499-2508. doi: 10.1093/cercor/bhy120.


Abe Y, Van Nguyen K, Tsurugizawa T, Ciobanu L, Le Bihan D

Modulation of water diffusion by activation-induced neural cell swelling in Aplysia Californica

Scientific Reports, 2017, Jul 21;7(1):6178. doi: 10.1038/s41598-017-05586-5.

Abe Y, Tsurugizawa T, Le Bihan D

Water diffusion closely reveals neural activity status in rat brain loci affected by anesthesia

PLoS Biology, 2017, Apr 13;15(4):e2001494. doi: 10.1371/journal.pbio.2001494. eCollection 2017 Apr.

Tsurugizawa T*, Abe Y, Le Bihan D

Water apparent diffusion coefficient correlates with gamma oscillation of local field potentials in the rat brain nucleus accumbens following alcohol injection

Journal of Cerebral Blood Flow and Metabolism, 2017, Sep;37(9):3193-3202. doi: 10.1177/0271678X16685104.


Tsurugizawa T*, Takahashi Y, Kato F

Distinct effects of isoflurane on basal BOLD signals in tissue/vascular microstructures in rats

Scientific Reports, 2016, Dec 15;6:38977. doi: 10.1038/srep38977.

Yoshida K, Mimura Y, Ishihara R, Nishida H, Komaki Y, Minakuchi T, Tsurugizawa T, Mimura M, Okano H, Tanaka KF, Takata N

Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe

J Neuroscience Methods, 2016, Dec 1;274:38-48. doi: 10.1016/j.jneumeth.2016.09.013.

Tsurugizawa T*, Tokuda S, Harada T, Takahashi T, Sadato N

Pharmacological and Expectancy Effects of a Low Amount of Alcohol Drinking on Outcome Valuation and Risk Perception in Males and Females

PLoS One, 2016, 11(4):e0154083. doi: 10.1371/journal.pone.0154083. eCollection 2016.

Selected publications before 2015

Uematsu A, Kitamura A, Iwatsuki K, Uneyama H, Tsurugizawa T

Correlation Between Activation of Prelimbic Cortex, the Basolateral Amygdala, and Agranular Insular Cortex During Taste Memory Formation

Cerebral Cortex, 2015, 25(9); 2719-28.

Tsurugizawa T*, Uneyama H

Differences in BOLD Responses to Intragastrically Infused Glucose and Saccharin in Rats

Chem Senses. 2014, Oct;39(8):683-91.

Iima M, Reynaud O, Tsurugizawa T, Ciobanu L, Li JR, Geffroy F, Djemai B, Umehana M, Le Bihan D

Non-Gaussian diffusion MRI assessment of microstructure in rat brain 9L glioma model

Investigative Radiology, 2014, Jul;49(7):485-90.

Tsurugizawa T*, Nogusa Y, Ando Y, Uneyama H

Different TRPV1-mediated brain responses to intragastric infusion of capsaicin and capsiate

European Journal of Neuroscience, 2013, Dec;38(11):3628-35.

Tsurugizawa T, Ciobanu L, Le Bihan D

Water diffusion in brain cortex closely tracks underlying neuronal activity

Proceedings of the National Academy of Sciences, 2013, Jul;110(28):11636-41.

Tsurugizawa T, Uematsu A, Uneyama H, Torii K

Functional brain mapping of conscious rats during reward anticipation

Journal of Neuroscience Methods, 2012, 206(2): 132-7.

Uematsu A, Tsurugizawa T, Uneyama H, Torii K

Brain-gut communication via vagus nerve modulate conditioned flavor preference

European Journal of Neurosciences, 2010, 31(6), 1136-1143.

Tsurugizawa T, Uematsu A, Uneyama H, Torii K

Effects of isoflurane and alpha-chloralose anesthesia on BOLD fMRI responses to ingested L-glutamate in rats

Neuroscience, 2010, 165(1), 244-51.

Tsurugizawa T, Uematsu A, Nakamura E, Hasumura M, Hirota M, Kondoh T, Uneyama H, Torii K

Mechanisms of neural response to gastrointestinal nutritive stimuli: the gut-brain axis

Gastroenterology, 2009, 137(1), 262-73.

Mukai H, Tsurugizawa T#, Murakami G, Kominami S, Ishii H, Ogiue-Ikeda M, Takata N, Tanabe N, Furukawa A, Hojo Y, Ooishi Y, Morrison JH, Janssen WG, Rose JA., Chambon P, Kato S, Izumi S, Yamazaki T, Kimoto T, Kawato S

Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons

Journal of Neurochemistry, 2007, 100(4), 950-67.

Tsurugizawa T, Mukai H, Tanabe N, Murakami G, Hojo Y, Kominami S, Mitsuhashi K, Komatsuzaki Y, Morrison JH, Janssen WG, Kimoto T, Kawato S

Estrogen induces rapid decrease in dendritic thorns of CA3 pyramidal neurons in adult male rat hippocampus

Biochemical and Biophysical Research Communications, 2005, 357(4), 1345-52.

Kimoto T, Tsurugizawa T, Ohta Y, Makino J, Tamura H, Hojo Y, Takata N and Kawato S

Neurosteroid Synthesis by Cytochrome P450-containing Systems Localized in the Rat Brain Hippocampal Neurons: N-Methyl-D-Aspartate and Calcium-dependent Synthesis

Endocrinology, 2001, 142, 3578-89.


Tsurugizawa T*.

Translational Magnetic Resonance Imaging in Autism Spectrum Disorder From the Mouse Model to Human

Front. Neurosci, 2022, May | https://doi.org/10.3389/fnins.2022.872036.

Kumamoto T*, Tsurugizawa T*.

Potential of multiscale astrocyte imaging for revealing mecha-nisms underlying neurodevelopmental disorders

Int J Mol Sci, 2021, Sep 24;22(19):10312.

Tsurugizawa T, Uneyama H, Torii K

Brain amino acid sensing

Diabetes Obes Metab, 2014, Sep;16 Suppl 1:41-8.

Tsurugizawa T

Neuroimaging of Gut Nutrient Perception

Curr Pharm Des, 2014, 20(16): 2738-44.

Tsurugizawa T and Torii K

Physiological roles of glutamate in gut and brain function

Biological and Pharmaceutical Bulletin, 2010, 33(11), 1796-9.

Mukai H, Tsurugizawa T, Ogiue-Ikeda M, Murakami G, Hojo Y, Ishii H, Kimoto T, Kawato S

Local neurosteroid production in the hippocampus: influence for synaptic plasticity of memory

Neuroendocrinology, 2006, 84(4), 255-263.

Tsurugizawa T, Torii K

Chapter 23 - Brain Amino Acid Sensing: The Use of a Rodent Model of Protein-Malnutrition, Lysine Deficiency

The Molecular Nutrition of Amino Acids and Proteins, Elsevier, 2014.