Research
Research of the functional network in the brain using Magnetic Resonance Imaging / Recherche du réseau fonctionnel dans le cerveau à l'aide de l'imagerie par résonance magnétique.
Translational research using fMRI / Le chercheur translationelle avec l'IRM
The disease model animal study is mondatory to unedrstand the mechanism of brain disease comprehensively. MRI is a promissing tool to investigate not only human brain but also animal brain funciton with same sequence. This is a great advantage for translational research. The purpose of this project developes the method of translatinal MRI study, with human and animal model, to investigate the brain function, structure and metabolism.
L'étude animale modèle de la maladie est indispensable pour comprendre le mécanisme de la maladie cérébrale. L'IRM est un outil prometteur pour étudier non seulement le cerveau humain mais aussi le fonctionnement du cerveau animal avec la même séquence. C'est un grand avantage pour la recherche translationnelle. Le but de ce projet est de développer la method de la cherche translatinalle avec l'IRM de l'homme et de la modele animale pour étudier la fonction, la structure et le métabolisme dans le cerveau.

Functional network in the brain / Le réseau fonctionelle dans le cerveau
Our brain exchanges the information between anatomically separated areas. The functional MRI signals, which reflect the neuronal activity, are synchronized between these regions. This synchronization is called as the functional network. In this project, we will discreminate the functional network of the brain computationally and will investigate the relationship of functional network with brain diseases.
Notre cerveau échange les informations entre des regions anatomiquement séparées. Les signaux IRM fonctionnels, qui reflètent l'activité neuronale, sont synchronisés entre ces régions. Cette synchronisation est appelée réseau fonctionnel. Dans ce projet, nous allons classifier le réseau fonctionnel du cerveau informatiquement et étudier la relation du réseau fonctionnel avec les maladies du cerveau.

Visualization of Glmphatic System / Visualisation du système glymphatique
Our brain has "Glymphatic System", a system for cleaning extra-substances. Our recent research has revealed the possibility of visualizing the activity of astrocytes, which play an important role in the glymphatic system, using diffusion-weighted MRI (Debacker S et al, 2020). This project pursues the possibility of diffusion-weighted MRI to challenges the visualization of the human glymphatic System.
Notre cerveau possède "le Système Glymphatique", un système de nettoyage des substances extra. Nous avons publié récentement un article de la possibilité de visualiser l'activité des astrocytes, qui sont importants dans le système glymphatique, en utilisant l'IRM diffusion (Debacker S et al, 2020). Ce projet explore la possibilité de l'IRM diffusion pour la visualisation du système glymphatique de l'homme.
Nutrition and brain function / La nutrition et le fonction du cerveau
We showed that fasting mice have higher functional connectivity among the hippocampus (memory), primary visual cortex and primary auditory cortex, compared to when they are full (Tsurugizawa et al, 2019). Furthermore, the intake of nutrients such as amino acids and carbohydrates, which are sources of brain energy and neuromodulator, changes the brain functional network. This project investigates the relationship between the nutrients and brain functional networks.
Nous avons publié un article que les souris mis à jeun ont une connectivité fonctionnelle plus élevée entre l'hippocampe (mémoire), le cortex visuel primaire et le cortex auditif primaire (Tsurugizawa et al, 2019). De plus, la consomation de les nutriments tel que les acides aminés et les glucides, qui sont des sources de l'énergie cérébrale et de la neuromodulateur, modifie le réseau fonctionnel du cerveau. Ce projet étudie la relation entre les nutriments et les réseaux fonctionnels du cerveau.
References
2023
Micro-magnetic resonance imaging of ex vivo mouse embryos with potato starch suspension
STAR Protocols. 2023 Jul 29;4(3):102483. doi: 10.1016/j.xpro.2023.102483.
Brain-wide mapping of resting-state networks in mice using high-frame rate functional ultrasound
NeuroImage. 2023 Jul 26;120297. doi: 10.1016/j.neuroimage.2023.120297.
Inflammation and subsequent nociceptor sensitization in the bone marrow are involved in an animal model of osteoarthritis pain
Life Science. 2023 Apr 28;121736. doi: 10.1016/j.lfs.2023.121736.
2022
Utilization of potato starch suspension for MR-microimaging in ex vivo mouse embryos
iScience. 2022 Nov 30, doi:10.1016/j.isci.2022.105694.
2021
Impact of anesthesia on static and dynamic functional connectivity in mice
NeuroImage. 2021 Jul 19. doi: 10.1016/j.neuroimage.2021.118413.
Fasting prevents medetomidine-induced hyperglycaemia and alterations of neurovascular coupling in the somatosensory cortex of the rat during noxious stimulation
European Journal of Neuroscience. 2021 Jun 16. doi: 10.1111/ejn.15350.
Cranioplastic Surgery and Acclimation Training for Awake Mouse fMRI
Bio-Protocol. 2020 Apr 5;11(7). doi: 10.21769/BioProtoc.3972.
*corresponding author
2020
fMRI detects bilateral brain network activation following unilateral chemogenetic activation of direct striatal projection neurons
NeuroImage. Accepted.
Differential Effects of aquaporin-4 Channel Inhibition on BOLD fMRI and Diffusion fMRI Responses in Mouse Visual Cortex
PLoS One. 2020 May 21;15(5):e0228759. doi: 10.1371/journal.pone.0228759. eCollection 2020.
Diffusion MRI Reveals in Vivo and Non-Invasively Changes in Astrocyte Function Induced by an aquaporin-4 Inhibitor
PLoS One. 2020 May 15;15(5):e0229702. doi: 10.1371/journal.pone.0229702. eCollection 2020.
Awake functional MRI detects neural circuit dysfunction in a mouse model of autism
Sci Adv. 2020 Feb 5;6(6):eaav4520. doi: 10.1126/sciadv.aav4520.
*corresponding author
2019
A New Tool for In Vivo Study of Astrocyte Connexin 43 in Brain
Sci Rep. 2019 Dec 4;9(1):18292. doi: 10.1038/s41598-019-54858-9.
#Equally conntributed
Primary role of the amygdala in spontaneous inflammatory pain-associated activation of pain networks – a chemogenetic manganese-enhanced MRI approach
Front. Neural Circuits, 2019. doi: 10.3389/fncir.2019.00058.
Mesoscopic and microscopic imaging of sensory responses in the same animal
Nat Commun. 2019 Mar 7;10(1):1110. doi: 10.1038/s41467-019-09082-4.
Spatial contribution of hippocampal BOLD activation in high-resolution fMRI
Sci Rep. 2019 Feb 28;9(1):3152. doi: 10.1038/s41598-019-39614-3.
The impact of fasting on resting state brain networks in mice
Sci Rep. 2019 Feb 27;9(1):2976. doi: 10.1038/s41598-019-39851-6.
Ingested d-Aspartate Facilitates the Functional Connectivity and Modifies Dendritic Spine Morphology in Rat Hippocampus
Cereb Cortex. 2019 Jun 1;29(6):2499-2508. doi: 10.1093/cercor/bhy120.
2017
Modulation of water diffusion by activation-induced neural cell swelling in Aplysia Californica
Sci Rep, 2017, Jul 21;7(1):6178. doi: 10.1038/s41598-017-05586-5.
Water diffusion closely reveals neural activity status in rat brain loci affected by anesthesia
PLoS Biol, 2017, Apr 13;15(4):e2001494. doi: 10.1371/journal.pbio.2001494. eCollection 2017 Apr.
Water apparent diffusion coefficient correlates with gamma oscillation of local field potentials in the rat brain nucleus accumbens following alcohol injection
J Cereb Blood Flow Metab, 2017, Sep;37(9):3193-3202. doi: 10.1177/0271678X16685104.
2016
Distinct effects of isoflurane on basal BOLD signals in tissue/vascular microstructures in rats
Sci Rep, 2016, Dec 15;6:38977. doi: 10.1038/srep38977.
Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe
J Neurosci Methods, 2016, Dec 1;274:38-48. doi: 10.1016/j.jneumeth.2016.09.013.
Pharmacological and Expectancy Effects of a Low Amount of Alcohol Drinking on Outcome Valuation and Risk Perception in Males and Females
PLoS One, 2016, 11(4):e0154083. doi: 10.1371/journal.pone.0154083. eCollection 2016.
Representative articles before 2015 / Articles représentatifs avant 2015
Correlation Between Activation of Prelimbic Cortex, the Basolateral Amygdala, and Agranular Insular Cortex During Taste Memory Formation
Cerebral Cortex, 2015, 25(9); 2719-28.
Differences in BOLD Responses to Intragastrically Infused Glucose and Saccharin in Rats
Chem Senses. 2014, Oct;39(8):683-91.
Non-Gaussian diffusion MRI assessment of microstructure in rat brain 9L glioma model
Investigative Radiology, 2014, Jul;49(7):485-90.
Different TRPV1-mediated brain responses to intragastric infusion of capsaicin and capsiate
European Journal of Neurosciences, 2013, Dec;38(11):3628-35.
Water diffusion in brain cortex closely tracks underlying neuronal activity
Proc Natl Acad Sci U S A., 2013, Jul;110(28):11636-41.
Functional brain mapping of conscious rats during reward anticipation
Journal of Neuroscience Methods, 2012, 206(2): 132-7.
Brain-gut communication via vagus nerve modulate conditioned flavor preference
European Journal of Neurosciences, 2010, 31(6), 1136-1143.
Effects of isoflurane and alpha-chloralose anesthesia on BOLD fMRI responses to ingested L-glutamate in rats
Neuroscience, 2010, 165(1), 244-51.
Mechanisms of neural response to gastrointestinal nutritive stimuli: the gut-brain axis
Gastroenterology, 2009, 137(1), 262-73.
Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons
Journal of Neurochemistry, 2007, 100(4), 950-67.
Estrogen induces rapid decrease in dendritic thorns of CA3 pyramidal neurons in adult male rat hippocampus
Biochemical and Biophysical Research Communications, 2005, 357(4), 1345-52.
Neurosteroid Synthesis by Cytochrome P450-containing Systems Localized in the Rat Brain Hippocampal Neurons: N-Methyl-D-Aspartate and Calcium-dependent Synthesis
Endocrinology, 2001, 142, 3578-89.
Review
Brain amino acid sensing
Diabetes Obes Metab, 2014, Sep;16 Suppl 1:41-8.
Neuroimaging of Gut Nutrient Perception
Curr Pharm Des, 2014, 20(16): 2738-44.
Physiological roles of glutamate in gut and brain function
Biological and Pharmaceutical Bulletin, 2010, 33(11), 1796-9.
Local neurosteroid production in the hippocampus: influence for synaptic plasticity of memory
Neuroendocrinology, 2006, 84(4), 255-263.
Chapter 23 - Brain Amino Acid Sensing: The Use of a Rodent Model of Protein-Malnutrition, Lysine Deficiency
The Molecular Nutrition of Amino Acids and Proteins, Elsevier, 2014.
Recruit for students and research fellows / Recruitment des étudientset chercheurs
I always welcome ph.D. students and research fellows who are interested in my research. Do not hesitate to contact me by e-mail.
Je me réjouis toujours des étudiants ph.D. et des chercheurs qui s'intéressent à mes recherches. N'hésitez pas à me contacter par e-mail.
e-mail adress: t-tsurugizawa@aist.go.jp
Contact
Location:National Institute of Advanced Industrial Science and Technology (AIST)
Human Information Interaction Research Institute Neurorehabilitation Research Group
1-1-1, Umezono, Tsukuba-shi, Ibaraki, 3058560, Japan