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Project

Single cell

Press release

  1. Development of technology for profiling the sugar chains of individual cells
  2. Development of a photo-reactive surface for single-cell analysis of cell-cell interactions - with potential applications in cancer immunotherapy

Original articles

  1. Bioorthogonal Photoreactive Surfaces for Single-Cell Analysis of Intercellular Communications. Kosaka T, Yamaguchi S, Izuta S, Yamahira S, Shibasaki Y, Tateno H, Okamoto A. J Am Chem Soc. 2022 Oct 5;144(39):17980-17988. doi: 10.1021/jacs.2c07321.
  2. Glycan profiling of the gut microbiota by Glycan-seq. Oinam L, Minoshima F, Tateno H. ISME COMMUN. 2, 1 (2022). doi: https://doi.org/10.1038/s43705-021-00084-2.
  3. Integrated analysis of glycan and RNA in single cells. Minoshima F, Ozaki H, Odaka H, Tateno H. iScience. 2021 Jul 17;24(8):102882. doi: 10.1016/j.isci.2021.102882. eCollection 2021 Aug 20. PMID: 34401666
  4. Clec10a regulates mite-induced dermatitis. Kanemaru K, Noguchi E, Tahara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, Sugiyama F, Takahashi S, Shibuya K, Shibuya A. Sci Immunol. 2019 Dec 6;4(42).
  5. Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint. Giron LB, Papasavvas E, Azzoni L, Yin X, Anzurez A, Damra M, Mounzer K, Kostman JR, Sanne I, Firnhaber CS, Tateno H, Liu Q, Montaner LJ, Abdel-Mohsen M. AIDS. 2020 Jan 17.
  6. Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection. Giron LB, Tanes CE, Schleimann MH, Engen PA, Mattei LM, Anzurez A, Damra M, Zhang H, Bittinger K, Bushman F, Kossenkov A, Denton PW, Tateno H, Keshavarzian A, Landay AL, Abdel-Mohsen M. Mucosal Immunol. 2020 Mar 9.

Virus

Press release

  1. Discovery of a peptide that inhibits infection by the new coronavirus

Original articles

  1. Core fucose-specific Pholiota squarrosa lectin (PhoSL) as a potent broad-spectrum inhibitor of SARS-CoV-2 infection. Yamasaki K, Adachi N, Ngwe Tun MM, Ikeda A, Moriya T, Kawasaki M, Yamasaki T, Kubota T, Nagashima I, Shimizu H, Tateno H, Morita K. FEBS J. 2022 Aug 25:10.1111/febs.16599. doi: 10.1111/febs.16599.
  2. A glycosaminoglycan microarray identifies the binding of SARS-CoV-2 spike protein to chondroitin sulfate E. Watanabe T, Takeda K, Hiemori K, Minamisawa T, Tateno H. FEBS Lett. 2021 Aug 10:10.1002/1873-3468.14173. doi: 10.1002/1873-3468.14173. Online ahead of print. PMID: 34375459
  3. Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection. Giron LB, Tanes CE, Schleimann MH, Engen PA, Mattei LM, Anzurez A, Damra M, Zhang H, Bittinger K, Bushman F, Kossenkov A, Denton PW, Tateno H, Keshavarzian A, Landay AL, Abdel-Mohsen M. Mucosal Immunol. 2020 Mar 9.
  4. Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint. Giron LB, Papasavvas E, Azzoni L, Yin X, Anzurez A, Damra M, Mounzer K, Kostman JR, Sanne I, Firnhaber CS, Tateno H, Liu Q, Montaner LJ, Abdel-Mohsen M. AIDS. 2020 Jan 17.
  5. Interferon-α alters host glycosylation machinery during treated HIV infection. Giron LB, Colomb F, Papasavvas E, Azzoni L, Yin X, Fair M, Anzurez A, Damra M, Mounzer K, Kostman JR, Tebas P, O'Doherty U, Tateno H, Liu Q, Betts MR, Montaner LJ, Abdel-Mohsen M. EBioMedicine. 2020 Sep;59:102945. doi: 10.1016/j.ebiom.2020.102945. Epub 2020 Aug 19. PMID: 32827942
  6. Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy. Colomb F, Giron LB, Kuri-Cervantes L, Adeniji OS, Ma T, Dweep H, Battivelli E, Verdin E, Palmer CS, Tateno H, Kossenkov AV, Roan NR, Betts MR, Abdel-Mohsen M. Cell Rep. 2020 Aug 4;32(5):107991. doi: 10.1016/j.celrep.2020.107991. PMID: 32755584

Exosome

Press release

  1. Evaluation of the diversity of extracellular vesicles by surface glycan pattern analysis

Original articles

  1. Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications. Asako Shimoda A, Miura R, Tateno H, Seo N, Shiku H, Sawada S, Sasaki Y, Akiyoshi K.
  2. Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays. Odaka H, Hiemori K, Shimoda A, Akiyoshi K, Tateno H. FEBS Open Bio. 2021 Mar;11(3):741-752. doi: 10.1002/2211-5463.13068. Epub 2021 Feb 3. PMID: 33345458
  3. Glycome analysis of extracellular vesicles derived from human induced pluripotent stem cells using lectin microarray. Saito S, Hiemori K, Kiyoi K, Tateno H(CA). Sci Rep. 2018 Mar 5;8(1):3997.

Cancer

Press release

  1. Lectin fusion drugs target the sugar chains on the surface of pancreatic cancer cells - Towards the development of a new anticancer treatment as a post-antibody drug -

Original articles

  1. Lectin-based phototherapy targeting cell surface glycans for pancreatic cancer. Kuroda Y, Oda T, Shimomura O, Hashimoto S, Akashi Y, Miyazaki Y, Furuya K, Furuta T, Nakahashi H, Louphrasitthiphol P, Mathis BJ, Nakajima T, Tateno H. Int J Cancer. 2023 Apr 1;152(7):1425-1437. doi: 10.1002/ijc.34362.
  2. rBC2LCN-reactive SERPINA3 is a glycobiomarker candidate for pancreatic ductal adenocarcinoma. Mawaribuchi S, Shimomura O, Oda T, Hiemori K, Shimizu K, Yamase K, Date M, Tateno H. Glycobiology. 2023 May 17;33(4):342-352. doi: 10.1093/glycob/cwad009.
  3. Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: 18 F-labeled rBC2LCN lectin. Kuroda Y, Oda T, Shimomura O, Louphrasitthiphol P, Mathis BJ, Tateno H, Hatano K. Cancer Sci. 2023 Aug;114(8):3364-3373. doi: 10.1111/cas.15846.
  4. Carcinoembryonic antigen as a specific glycoprotein ligand of rBC2LCN lectin on pancreatic ductal adenocarcinoma cells. Furuta T, Oda T, Kiyoi K, Ozawa Y, Kimura S, Kurimori K, Miyazaki Y, Yu Y, Furuya K, Akashi Y, Shimomura O, Tateno H. Cancer Sci. 2021 Jun 11. doi: 10.1111/cas.15023. Online ahead of print. PMID: 34115906
  5. Quantitative structural analysis of glycans expressed within tumors derived from pancreatic cancer patient-derived xenograft mouse models. Hasehira K, Furuta T, Shimomura O, Asada M, Oda T, Tateno H. Biochem Biophys Res Commun. 2021 Jan 1;534:310-316. doi: 10.1016/j.bbrc.2020.11.087. Epub 2020 Dec 4. PMID: 33288196
  6. Lectin drug conjugate therapy for colorectal cancer. Kitaguchi D, Oda T, Enomoto T, Ohara Y, Owada Y, Akashi Y, Furuta T, Yu Y, Kimura S, Kuroda Y, Kurimori K, Miyazaki Y, Furuya K, Shimomura O, Tateno H. Cancer Sci. 2020 Oct 15. doi: 10.1111/cas.14687. Online ahead of print. PMID: 33058342
  7. rBC2LCN lectin as a potential probe of early-stage HER2-positive breast carcinoma. Mawaribuchi S, Haramoto Y, Tateno H, Onuma Y, Aiki Y, Ito Y. FEBS Open Bio. 2020 Mar 31.
  8. A Novel Therapeutic Strategy for Pancreatic Cancer: Targeting Cell Surface Glycan Using rBC2LC-N Lectin-Drug Conjugate (LDC). Shimomura O, Oda T, Tateno H, Ozawa Y, Kimura S, Sakashita S, Noguchi M, Hirabayashi J, Asashima M, Ohkohchi N.Mol Cancer Ther. 2018 Jan;17(1):183-195.

Bacteria

Original articles

  1. Glycan profiling of the gut microbiota by Glycan-seq. Oinam L, Minoshima F, Tateno H. ISME COMMUN. 2, 1 (2022). doi: https://doi.org/10.1038/s43705-021-00084
  2. Lectin microarray reveals binding profiles of Lactobacillus casei strains in a comprehensive analysis of bacterial cell wall polysaccharides. Yasuda E, Tateno H, Hirabayashi J, Iino T, Sako T. Appl Environ Microbiol. 2011 Jul;77(13):4539-46.

Neurodegenerative / mental disorder

Press release

  1. Mental stress alters the glycan structure of the intestinal epithelium - confirmed in mice and used to elucidate the mechanism of the gut-bacteria-gut-brain relationship

Original articles

  1. Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays. Odaka H, Hiemori K, Shimoda A, Akiyoshi K, Tateno H. FEBS Open Bio. 2021 Mar;11(3):741-752. doi: 10.1002/2211-5463.13068. Epub 2021 Feb 3. PMID: 33345458
  2. Reduced fucosylation in the distal intestinal epithelium of mice subjected to chronic social defeat stress. Omata Y, Aoki R, Aoki-Yoshida A, Hiemori K, Toyoda A, Tateno H, Suzuki C, Takayama Y. Sci Rep. 2018 Sep 4;8(1):13199.

Stem cells

Press release

  1. Success in analyzing changes in the sugar chains of skin stem cells associated with aging
  2. Development of technology that can evaluate the ability of human mesenchymal stem cells to differentiate - Contributing to practical application in regenerative medicine through simple and rapid evaluation -
  3. Development of technology to remove human iPS/ES cells that cause tumors from transplanted cells - Enabling the risk of tumor development in regenerative medicine to be reduced -
  4. Enabling the safety of cells used in regenerative medicine to be tested in culture fluid
  5. Development of a probe that can visualize human iPS cells in living tissue
  6. Precise evaluation of iPS cells using rapid glycan profiling technology

Original articles

  1. Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging. Oinam L, Changarathil G, Raja E, Ngo YX, Tateno H, Sada A, Yanagisawa H. Aging Cell. 2020 Jul 18:e13190. doi: 10.1111/acel.13190. Online ahead of print. PMID: 32681764
  2. Elimination of cells deviated from human induced pluripotent stem cells with a photoactivatable IR700-labelled antibody. Watanabe T, Tateno H. Biochem Biophys Res Commun. 2021 May 21;554:13-18. doi: 10.1016/j.bbrc.2021.03.078. Epub 2021 Mar 25. PMID: 33774274
  3. Monoclonal antibodies specific for podocalyxin expressed on human induced pluripotent stem cells. Watanabe T, Kakuta J, Saito S, Hasehira K, Kiyoi K, Imai T, Tateno H Biochem Biophys Res Commun. 2020 Nov 19;532(4):647-654. doi: 10.1016/j.bbrc.2020.08.092. Epub 2020 Sep 7. PMID: 32912628
  4. SSEA-1-positive fibronectin is secreted by cells deviated from the undifferentiated state of human induced pluripotent stem cells. Watanabe T, Saito S, Hiemori K, Kiyoi K, Mawaribuchi S, Haramoto Y, Tateno H. Biochem Biophys Res Commun. 2020 Aug 27;529(3):575-581. doi: 10.1016/j.bbrc.2020.06.074. Epub 2020 Jul 15. PMID: 32736676
  5. Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging. Oinam L, Changarathil G, Raja E, Ngo YX, Tateno H, Sada A, Yanagisawa H. Aging Cell. 2020 Jul 18:e13190. doi: 10.1111/acel.13190. Online ahead of print. PMID: 32681764
  6. Oriented immobilization of rBC2LCN lectin for highly sensitive detection of human pluripotent stem cells using cell culture supernatants. *Tateno H(CA), Hiemori K, Minoshima F, Kiyoi K, Matoba K, Katayama J, Kumada Y. J Biosci Bioeng. 2019 in press
  7. Photoactivable elimination of tumorigenic human induced pluripotent stem cells using a lectin-doxorubicin prodrug conjugate. Dion J, Minoshima F, Saito S, Kiyoi K, Hasehira K, Tateno H(CA). Chembiochem. 2019 Jun 14;20(12):1606-1611.
  8. Engineering of a Potent Recombinant Lectin-Toxin Fusion Protein to Eliminate Human Pluripotent Stem Cells. *Tateno H(CA), Fumi Minoshima, Saito S. Molecules. 2017 Jul 10;22(7). 
  9. Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media. *Tateno H(CA), Hiemori K, Hirayasu K, Sougawa N, Fukuda M, Warashina M, Amano M, Funakoshi T, Sadamura Y, Miyagawa S, Saito A, Sawa Y, Shofuda T, Sumida M, Kanemura Y, Nakamura M, Okano H, Onuma Y, Ito Y, Asashima M, Hirabayashi. Regenerative Therapy 2017; 6:1-8.
  10. Structural and quantitative evidence of α2-6-sialylated N-glycans as markers of the differentiation potential of human mesenchymal stem cells. Hasehira K, Hirabayashi J, Tateno H(CA). Glycoconj J. 2017 Dec;34(6):797-806.
  11. Elimination of tumorigenic human pluripotent stem cells by a recombinant lectin-toxin fusion protein. *Tateno H(CA), Onuma Y, Ito Y, Minoshima F, Saito S, Shimizu M, Aiki Y, Asashima M, Hirabayashi J. Stem Cell Reports. 2015 May 12;4(5):811-20.
  12. A medium hyperglycosylated podocalyxin enables noninvasive and quantitative detection of tumorigenic human pluripotent stem cells. *Tateno H(CA), Onuma Y, Ito Y, Hiemori K, Aiki Y, Shimizu M, Higuchi K, Fukuda M, Warashina M, Honda S, Asashima M, Hirabayashi J. Sci Rep. 2014 Feb 12;4:4069.
  13. Structural and quantitative evidence for dynamic glycome shift on production of induced pluripotent stem cells. Hasehira K, Tateno H, Onuma Y, Ito Y, Asashima M, Hirabayashi J. Mol Cell Proteomics. 2012 Dec;11(12):1913-23. 
  14. α2-6sialylation is a marker of the differentiation potential of human mesenchymal stem cells. *Tateno H(CA), Saito S, Hiemori K, Kiyoi K, Hasehira K, Toyoda M, Onuma Y, Ito Y, Akutsu H, Hirabayashi J. Glycobiology. 2016 Dec;26(12):1328-1337.
  15. Possible linkages between the inner and outer cellular states of human induced pluripotent stem cells. Saito S, Onuma Y, Ito Y, *Tateno H (equal contribution), Toyoda M, Hidenori A, Nishino K, Chikazawa E, Fukawatase Y, Miyagawa Y, Okita H, Kiyokawa N, Shimma Y, Umezawa A, Hirabayashi J, Horimoto K, Asashima M. BMC Syst Biol. 2011 Jun 20;5 Suppl 1:S17. 
  16. Glycome diagnosis of human induced pluripotent stem cells using lectin microarray. *Tateno H, Toyota M, Saito S, Onuma Y, Ito Y, Hiemori K, Fukumura M, Matsushima A, Nakanishi M, Ohnuma K, Akutsu H, Umezawa A, Horimoto K, Hirabayashi J, Asashima M. J Biol Chem. 2011 Jun 10;286(23):20345-53. 

Lectins

Press release

  1. Discovery of a molecule that suppresses atopic dermatitis caused by mites

Original articles

  1. Self-Assembling Lectin Nano-Block Oligomers Enhance Binding Avidity to Glycans. Irumagawa S, Hiemori K, Saito S, Tateno H, Arai R. Int J Mol Sci. 2022 Jan 8;23(2):676. doi: 10.3390/ijms23020676.
  2. Oriented immobilization of rBC2LCN lectin for highly sensitive detection of human pluripotent stem cells using cell culture supernatants. *Tateno H(CA), Hiemori K, Minoshima F, Kiyoi K, Matoba K, Katayama J, Kumada Y. J Biosci Bioeng. 2019 in press
  3. Structural basis for specific recognition of core fucosylation in N-glycans by Pholiota squarrosa lectin (PhoSL). Yamasaki K, Kubota T, Yamasaki T, Nagashima I, Shimizu H, Terada RI, Nishigami H, Kang J, Tateno M, Tateno H. Glycobiology. 2019 Jul 1;29(7):576-587.
  4. Photoactivable elimination of tumorigenic human induced pluripotent stem cells using a lectin-doxorubicin prodrug conjugate. Dion J, Minoshima F, Saito S, Kiyoi K, Hasehira K, Tateno H(CA). Chembiochem. 2019 Jun 14;20(12):1606-1611.
  5. Engineering of a Potent Recombinant Lectin-Toxin Fusion Protein to Eliminate Human Pluripotent Stem Cells. *Tateno H(CA), Fumi Minoshima, Saito S. Molecules. 2017 Jul 10;22(7).
  6. Engineering of recombinant Wisteria floribunda agglutinin specifically binding to GalNAcβ1,4GlcNAc (LacdiNAc). Sato T, Tateno H, Kaji H, Chiba Y, Kubota T, Hirabayashi J, Narimatsu H. Glycobiology. 2017 May 26.
  7. Engineering of a Potent Recombinant Lectin-Toxin Fusion Protein to Eliminate Human Pluripotent Stem Cells. *Tateno H(CA), Fumi Minoshima, Saito S. Molecules. 2017 Jul 10;22(7).
  8. Engineering of a 3'-sulpho-Galβ1-4GlcNAc-specific probe by a single amino acid substitution of a fungal galectin. Hu D, Huang H, Tateno H, Nakakita S, Sato T, Narimatsu H, Yao X, Hirabayashi J. J Biochem. 2015 Apr;157(4):197-200.
  9. Mammalian Cell Surface Display as a Novel Method for Developing Engineered Lectins with Novel Characteristics. Soga K, Abo H, Qin SY, Kyoutou T, Hiemori K, Tateno H, Matsumoto N, Hirabayashi J, Yamamoto K. Biomolecules. 2015 Jul 20;5(3):1540-62.
  10. Tailoring GalNAcα1-3Galβ-specific lectins from a multi-specific fungal galectin: dramatic change of carbohydrate specificity by a single amino-acid substitution. Hu D, Tateno H, Sato T, Narimatsu H, Hirabayashi J. Biochem J. 2013 Jul 15;453(2):261-70. 
  11. Engineering of the glycan-binding specificity of Agrocybe cylindracea galectin towards α(2,3)-linked sialic acid by saturation mutagenesis. Imamura K, Takeuchi H, Yabe R, Tateno H, Hirabayashi J. J Biochem. 2011 Nov;150(5):545-52.
  12. Directed evolution of lectins with sugar-binding specificity for 6-sulfo-galactose. Hu D, Tateno H, Kuno A, Yabe R, Hirabayashi J. J Biol Chem. 2012 Jun 8;287(24):20313-20.