@@Shinji Sugiura

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Research

My research expertise is biochemical engineering, microelectromechanical systems (MEMS) technologies, biomaterials and cell biology. I have worked on the application of MEMS technology to material fabrication and cell-based assay. Now, I am starting to apply MEMS technologies to stem cell research and tissue engineering.

I started my research carrier in Sekifs lab in the University of Tokyo, and studied biochemical engineering. I met MEMS technology in Nakajimafs laboratory in National Food Research Institute (NFRI), where I was a visiting student in 1997. I had a strong interest in the application of MEMS technology to material engineering and biotechnology. At the same time, a big research project on the application of MEMS technology to droplet formation and material fabrication started in the NFRI. I was tempted to join to the project and decided to study on the microfluidic droplet formation and material fabrication as my graduate research. I worked on this project from 1998 to 2002. I studied with 6 younger students and taught them the experimental techniques and theories. My achievements in this project were published as 20 scientific papers and 5 patents.

In the project in NFRI, the collaborated project with National Cancer Center (NCC) started on 2001. The purpose of the project was development of cancer treatment method by using microcapsules containing cells producing anticancer drug proteins. My role was development of the method to generate small microcapsules and preparation of microcapsules containing cells. After my graduation in 2002, I joined this project as a post-doctoral researcher. In this period, I worked with physicians in NCC and learned a lot of techniques for biological experiment, especially for cancer biology. My achievements in this project were published as 5 scientific papers.

After 2 year post-doctoral research, I found a timely recruitment for tenure-track scientist position in National Institute of Advanced Industrial Science and Technology (AIST). After joining AIST, I had an interest not only in the scientific research, but also in developmental research for industrial application. I have investigated cell-based assay and cell manipulation techniques combining MEMS technologies and material chemistry. I developed integrated perfusion culture microchamber array for high-through put drug screening. I also developed the technologies for microfluid control and cell micropatterning by using photoresponsive polymer and micropatterned light irradiation system. My achievements in AIST were published in more than 15 scientific papers and 6 patents. Through these works, I obtained tenured position in 2009. Some of the achieved researches were preceded toward the industrial application and several collaborated studies with companies are now under progress. Now, I believe the MEMS technology is useful and advantageous technology for stem cell research and tissue engineering. Especially, I am very interested in stem cell differentiation in controlled microenvironment.


Last updated 17th April, 2001
Shinji Sugiura