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Bio/synthetic polymer team

Health and Medical Research Institute
National Institute of Advanced Industrial Science and Technology (AIST)

MEMBERV’…î•ñ




Shunsuke Tomita / •y“c s‰î
@Senior Reseacher / Žå”CŒ¤‹†ˆõ
@For more information



Masahiro Mimura / ŽO‘º ^‘å
@3rd-year Ph.D. student, JSPS Young Research Fellow / ”ŽŽmŒãŠú‰Û’öiD3, ŠwUDC2, ŒI“cŒ¤‹†ŽºŠ‘®j

@Achievement in our team
  1. Uncharged components of single-stranded DNA modulate liquid?liquid phase separation with cationic linker histone H1.
    Masahiro Mimura, Shunsuke Tomita, Hiroka Sugai, Yoichi Shinkai, Sayaka Ishihara, Ryoji Kurita
    Frontiers in Cell and Developmental Biology, 9, 710729 (2021).

  2. Quadruplex folding promotes the condensation of linker histones and DNAs via liquid-liquid phase separation.
    Masahiro Mimura, Shunsuke Tomita, Yoichi Shinkai, Takuya Hosokai, Hiroyuki Kumeta, Tomohide Saio, Kentaro Shiraki, Ryoji Kurita
    Journal of the American Chemical Society, 143, 9849-9857 (2021).
    ChemRxiv, DOI: 10.26434/chemrxiv.11822076 (2021)


  3. Affinity diversification of a polymer probe for pattern-recognition-based biosensing using chemical additives.
    Hiroki Okada, Masahiro Mimura, Shunsuke Tomita, Ryoji Kurita
    Analytical Sciences, 37, 713-719 (2021).


  4. Optical fingerprints of proteases and their inhibited complexes provided by differential cross-reactivity of fluorophore-labeled single-stranded DNA.
    Shunsuke Tomita, Hiroka Sugai, Masahiro Mimura, Sayaka Ishihara, Kentaro Shiraki, Ryoji Kurita
    ACS Applied Materials & Interfaces, 11, 47428-47436 (2019)


  5. Array-based generation of response patterns with common fluorescent dyes for identification of proteins and cells.
    Masahiro Mimura, Shunsuke Tomita, Ryoji Kurita, Kentaro Shiraki
    Analytical Sciences
    , 35, 99-102 (2019)


  6. “Á•ÊŒ¤‹†ˆõDC2, “ú–{ŠwpU‹»‰ï(2020/4-2022/3)

  7. 2019”N“x SUMBOR SCHOLARSHIP, Œö‰và’c–@l ƒTƒ“ƒgƒŠ[¶–½‰ÈŠwà’c (2019/4-2022/3)

  8. §—ãÜ, ‘æ29‰ñ“ú–{MRS”NŽŸ‘å‰ï (2019)

  9. —DGÜ, ‘æ34‰ñ‚•ªŽqŠw‰ïˆïé’n‹æuŽáŽè‚̉ïvŒð—¬‰ï (2019)

  10. —DGƒ|ƒXƒ^[Ü, ‘æ‚W‰ñ Chem-Bio Joint Seminar 2019 (2019)

  11. Best Poster Award, ASUKAƒVƒ“ƒ|ƒWƒEƒ€2019 (2019)

  12. —DGƒ|ƒXƒ^[Ü, •½¬30”N“x“Œ“ú–{•ªÍ‰»ŠwŽáŽèŒð—¬‰ï (2018)




Hiroka Sugai / ›ˆä Ë‰Á
@Visiting researcher / ŽYŠwŠ¯§“x—ˆŠŽÒi•‹³, ’}”g‘åŠw ”’–ØŒ¤‹†Žºj

@Achievement in our team
  1. Uncharged components of single-stranded DNA modulate liquid?liquid phase separation with cationic linker histone H1.
    Masahiro Mimura, Shunsuke Tomita, Hiroka Sugai, Yoichi Shinkai, Sayaka Ishihara, Ryoji Kurita
    Frontiers in Cell and Developmental Biology, 9, 710729 (2021).

  2. A microfluidic sensing system with a multichannel surface plasmon resonance chip: Damage-free characterization of cells by pattern recognition
    Hiroka Sugai, Shunsuke Tomita, Sayaka Ishihara, Kyoko Yoshioka, Ryoji Kurita
    Analytical Chemistry, 92, 14939-14946 (2020)
    ChemRxiv, DOI: 10.26434chemrxiv.12052422 (2020)


  3. A multichannel pattern-recognition-based protein sensor with a fluorophore-conjugated single-stranded DNA set
    Mari Okadaõ, Hiroka Sugaiõ, Shunsuke Tomita, Ryoji Kurita
    Sensors, 20, 5110 (2020) õequally contributed.


  4. Pattern-recognition-based Sensor arrays for cell characterization: From materials and data analyses to biomedical applications
    Shunsuke Tomita, Hiroka Sugai, Sayaka Ishihara, Takuya Hosokai, Ryoji Kurita
    Chemistry Letters, 49, 1447-1451 (2020)


  5. Pattern-based sensor arrays for cell characterization: From materials and data analyses to biomedical applications.
    Hiroka Sugai, Shunsuke Tomita, Ryoji Kurita
    Analytical Sciences, 36, 923-934 (2020).
    ¡ Selected as "Hot Articles"


  6. Optical fingerprints of proteases and their inhibited complexes provided by differential cross-reactivity of fluorophore-labeled single-stranded DNA.
    Shunsuke Tomita, Hiroka Sugai, Masahiro Mimura, Sayaka Ishihara, Kentaro Shiraki, Ryoji Kurita
    ACS Applied Materials & Interfaces, 11, 47428-47436 (2019)


  7. A one-component array based on a dansyl-modified polylysine: Generation of differential fluorescent signatures for the discrimination of human cells.
    Hiroka Sugai, Shunsuke Tomita, Sayaka Ishihara, Ryoji Kurita
    ACS Sensors, 4, 827-831 (2019)


  8. Fingerprint-based protein identification in cell culture medium using environment-sensitive turn-on fluorescent polymer.
    Hiroka Sugai, Shunsuke Tomita, Ryoji Kurita
    Sensors and Materials
    , 31, 1-11 (2019)


  9. “Á’¥ƒpƒ^[ƒ“‚Ì”FŽ¯.
    ›ˆä Ë‰ÁA•y“c s‰î
    in ‘Š•ª—£¶•¨Šw‚Ì‘S–e, pp.343-348. ”’–Ø Œ«‘¾˜Y •Ò, “Œ‹ž‰»Šw“¯l (2020)


  10. •ªŽqƒAƒŒƒCƒfƒoƒCƒX‚Æ‘½•Ï—ʉðÍ‚É‚æ‚鐶‘ÌŽŽ—¿•]‰¿–@.
    •y“c s‰îA›ˆä Ë‰ÁA“ì–Ø ‘nAŒI“c —»“ñ
    “d‹C‰»Šw
    , 88, 262-271 (2020)


  11. ¶‘ÌŽŽ—¿‚Ì“Á’¥î•ñ‚ðo—Í‚·‚éŒð·”½‰ž«ƒ|ƒŠƒ}[ƒAƒŒƒC‚ð—˜—p‚µ‚½ƒoƒCƒIƒƒgƒŠƒNƒX.
    ›ˆä Ë‰ÁA•y“c s‰îAŒI“c —»“ñ.
    ƒPƒ~ƒJƒ‹ƒGƒ“ƒWƒjƒ„ƒŠƒ“ƒO, 63, 58-65 (2018)


  12. ŽáŽè“Á•ÊÜ, SATƒeƒNƒmƒƒW[¥ƒVƒ‡[ƒP[ƒX2021 (2021).

  13. —DGƒ|ƒXƒ^[Ü, ‘æ14‰ñƒiƒmEƒoƒCƒIƒƒfƒBƒJƒ‹Šw‰ï (2019)



Sayaka Ishihara / ÎŒ´ ŽÑˆ»‰Ä
@Amazing technical staff / ‹ZpEˆõ



Tomoto Ura / ‰Y •ül
@Technical training, JSPS Young Research Fellow / ‹ZpŒ¤C¶ (D2, ŠwUDC1, ’}”g‘åŠw ”’–ØŒ¤‹†ŽºŠ‘®)

@Achievement in our team
  1. Dynamic formation of liquid droplets triggered by sequential enzymatic reactions.
    Tomoto Ura, Shunsuke Tomita, Kentaro Shiraki
    ChemRxiv, DOI: 10.26434/chemrxiv.11930403 (2020)




Yuto Akahoshi / Ô¯ —F“s
@Technical training / ‹ZpŒ¤C¶ (M2, ’}”g‘åŠw ”’–ØŒ¤‹†ŽºŠ‘®)



Kanou Shogo / Žë–ì ²Œá
@Technical training / ‹ZpŒ¤C¶ (B4, ’}”g‘åŠw ”’–ØŒ¤‹†ŽºŠ‘®)



Okubo Atsuya / ‘å‹v•Û “Ö–ç
@Technical training / ‹ZpŒ¤C¶ (B4, ’}”g‘åŠw ”’–ØŒ¤‹†ŽºŠ‘®)



Ryoji Kurita / ŒI“c —»“ñ (PI)
@Group Leader / Œ¤‹†ƒOƒ‹[ƒv’·
@For more information


ALUMNIV’…î•ñ

Hiroki Okada / ‰ª“c O‹B @”ŽŽm‘OŠú‰Û’ö C—¹i2021”Nj

@Achievement in our team
  1. Affinity diversification of a polymer probe for pattern-recognition-based biosensing using chemical additives.
    Hiroki Okada, Masahiro Mimura, Shunsuke Tomita, Ryoji Kurita
    Analytical Sciences,37, 713-719 (2021)




Mari Okada / ‰ª“c –€—˜ @”ŽŽm‘OŠú‰Û’ö C—¹i2021”Nj

@Achievement in our team
  1. A multichannel pattern-recognition-based protein sensor with a fluorophore-conjugated single-stranded DNA set
    Mari Okadaõ, Hiroka Sugaiõ, Shunsuke Tomita, Ryoji Kurita
    Sensors, 20, 5110 (2020) õequally contributed.


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