論文発表など - 花井@産総研

黄色は体内時計、赤はポリ(ADP-リボース)、緑はがん・HTLV1関連です。
Minamoto T, Hanai S, Kadota K, Oishi K, Matsumae H, Fujie M, Azumi K, Satoh N, Satake M, Ishida N.
Circadian clock in Ciona intestinalis revealed by microarray analysis and oxygen consumption.
J Biochem. 2009 Oct 25.
PMID: 19855119
Hanai S, Ishida N.
Entrainment of Drosophila circadian clock to green and yellow light by Rh1, Rh5, Rh6 and CRY.
Neuroreport. 2009 May 27;20(8):755-8.
PMID: 19398933
サイエンス最前線:研究者たちの素顔/4 体内時計と光の関係
毎日新聞 茨城 2008.11.19
Hanai S, Hamasaka Y, Ishida N.
Circadian entrainment to red light in Drosophila: requirement of Rh1 and Rh6
Neuroreport.2008 Sep 17;19(14):1441-4.
PMID: 18766027
Onishi Y, Hanai S, Ohno T, Hara Y, Ishida N.
Rhythmic SAF-A binding underlies circadian transcription of the Bmal1 gene.
Mol Cell Biol. 2008 May;28(10):3477-88. Epub 2008 Mar 10. PMID: 18332112 
時間生物学事典 「血中ホルモン」朝倉書店
きちんとわかる時計遺伝子「時計遺伝子の進化とモデル生物」白日社
Nitta T, Tanaka M, Sun B, Sugihara E, Kimura M, Kamada Y, Takahashi H, Hanai S, Jiang SW, Fujisawa J, Miwa M.
Reduction of human T-cell leukemia virus type-1 infection in mice lacking nuclear factor-kappaB-inducing kinase.
Cancer Sci. 2008 May;99(5):872-8. Epub 2008 Feb 27. PMID: 18312467
第7回産総研サイエンスカフェ「体内時計のはなし」2007年12月20日
"From Clock Genes to Drug Discovery for Sleep Rhythm Disorder"
Hanai S and Ishida N
International Symposium on Advances in Neurosciences
Kanai M, Hanashiro K, Kim SH, Hanai S, Boulares AH, Miwa M, Fukasawa K.
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation.
Nat Cell Biol. 2007 Oct;9(10):1175-83. Epub 2007 Sep 23. PMID: 17891139 
Honjo S, Srivatanakul P, Sriplung H, Kikukawa H, Hanai S, Uchida K, Todoroki T, Jedpiyawongse A, Kittiwatanachot P, Sripa B, Deerasamee S, Miwa M.
Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand.
Int J Cancer. 2005 Dec 10;117(5):854-60. PMID: 15957169
タンパク質科学イラストレイテッド 第3章7ポリADP-リボシル化
Watcharin Loilome, Puangrat Yongvanit, Chaisiri Wongkham, Nisana Tepsiri, Banchob Sripa, Paiboon Sithithaworn, Shuji HANAI, Masanao MIWA.
Altered Gene Expression in Opisthorchis viverrini-Associated Cholangiocarcinoma in Hamster Model
Molecular Carcinogenesis.2006 Mar 21 PMID: 16550611.
三輪正 直、金居正幸、杉原英志、大橋紗矢香、野木康子、花井修次.
ポリ-ADP-リボシル化による細胞機能、特に中心体と神経細胞機能の調節について
ビタミン, vol. 78: pp. 337-346, 2004. 7
三輪正 直、金居正幸、花井修次
ポリADPリボシル化研究の新展開,  実験 医学2004年6月号.
Hanai S, Masuo Y, Shirai H, Oishi K, Saida K, Ishida N.
Differential circadian expression of endothelin-1 mRNA in the rat suprachiasmatic nucleus and peripheral tissues.

Neurosci Lett. 2005 Mar 22;377(1):65-8. Epub 2004 Dec 22.
PMID: 15722189
Kobayashi H, Oishi K, Hanai S, Ishida N.
Effect of feeding on peripheral circadian rhythms and behaviour in mammals.
Genes Cells. 2004 Sep;9(9):857-64.
PMID: 15330862
Hanai, S., Nitta, T., Shoda, M., Tanaka, M., Iso, N., Mizoguchi, I., Yashiki, S., Sonoda, S., Hasegawa, Y., Nagasawa T., and Masanao Miwa
Integration of human T-cell leukemia virus type 1 in genes of leukemia cells of patients with adult T-cell leukemia
Cancer Sci. 2004 Apr;95(4):306-10.
PMID: 15072587
Hanai S, Kanai M, Ohashi S, Okamoto K, Yamada M, Takahashi H, Miwa M.
Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster.
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):82-6. Epub 2003 Dec 15.
PMID: 14676324
Nitta T, Tanaka M, Sun B, Hanai S, Miwa M.
The genetic background as a determinant of human T-cell leukemia virus type 1 proviral load.
Biochem Biophys Res Commun. 2003 Sep 12;309(1):161-5.
PMID: 12943677
Ohashi S, Kanai M, Hanai S, Uchiumi F, Maruta H, Tanuma S, Miwa M. 
Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells.
Biochem Biophys Res Commun. 2003 Aug 8;307(4):915-21.
PMID: 12878198
Sun B, Nitta T, Shoda M, Tanaka M, Hanai S, Hoshino H, Miwa M.
Cell-free human T-cell leukemia virus type 1 binds to, and efficiently enters mouse cells.
Jpn J Cancer Res. 2002 Jul;93(7):760-6. Erratum in: Jpn J Cancer Res. 2002 Aug;93(8):952.
PMID: 12149141
Uchida M, Hanai S, Uematsu N, Sawamoto K, Okano H, Miwa M, Uchida K.
Overexpression of poly(ADP-ribose) polymerase disrupts organization of cytoskeletal F-actin and tissue polarity in Drosophila.
J Biol Chem. 2002 Feb 22;277(8):6696-702. Epub 2001 Dec 13.
PMID: 11744702
Uchida M, Hanai S, Uematsu N, Sawamoto K, Okano H, Miwa M, Uchida K.
Genetic and functional analysis of PARP, a DNA strand break-binding enzyme.
Mutat Res. 2001 Jun 2;477(1-2):89-96.
PMID: 11376690
Tanaka M, Sun B, Fang J, Nitta T, Yoshida T, Kohtoh S, Kikukawa H, Hanai S, Uchida K, Miwa M.   
Human T-cell leukemia virus type 1 (HTLV-1) infection of mice: proliferation of cell clones with integrated HTLV-1 provirus in lymphoid organs.
J Virol. 2001 May;75(9):4420-3.
PMID: 11287593
Kanai M, Uchida M, Hanai S, Uematsu N, Uchida K, Miwa M.
Poly(ADP-ribose) polymerase localizes to the centrosomes and chromosomes.
Biochem Biophys Res Commun. 2000 Nov 19;278(2):385-9.
PMID: 11097846
Miwa M, Hanai S, Poltronieri P, Uchida M, Uchida K.
Functional analysis of poly(ADP-ribose) polymerase in Drosophila melanogaster.
Mol Cell Biochem. 1999 Mar;193(1-2):103-7.
PMID: 10331645
Koyama Y, Katagiri S, Hanai S, Uchida K, Miwa M.
Poly(ADP-ribose) polymerase interacts with novel Drosophila ribosomal proteins, L22 and l23a, with unique histone-like amino-terminal extensions.
Gene. 1999 Jan 21;226(2):339-45.
PMID: 9931508
Hanai S, Uchida M, Kobayashi S, Miwa M, Uchida K.
Genomic organization of Drosophila poly(ADP-ribose) polymerase and distribution of its mRNA during development.
J Biol Chem. 1998 May 8;273(19):11881-6.
PMID: 9565614
Poltronieri P, Yokota T, Koyama Y, Hanai S, Uchida K, Miwa M.  
PARP cleavage in the apoptotic pathway in S2 cells from Drosophila melanogaster.
Biochem Cell Biol. 1997;75(4):445-9.
PMID: 9493967
Yoshida S, Todoroki T, Ichikawa Y, Hanai S, Suzuki H, Hori M, Fukao K, Miwa M, Uchida K.
Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers.
Cancer Res. 1995 Jul 1;55(13):2756-60.
PMID: 7796400
Miwa M, Hanai S, Masuda H, Koyama Y, Hayashi T, Yoshida Y, Poltronieri P, Maeshima K, Kobayashi S, Okada M, Uchida K
Analysis of biological function of poly(ADP-ribosyl)ation in Drosophila melanogaster.
Biochimie. 1995;77(6):466-71. Review.
PMID: 7578431
Uchida K, Uchida M, Hanai S, Ozawa Y, Ami Y, Kushida S, Miwa M.
Isolation of the poly(ADP-ribose) polymerase-encoding cDNA from Xenopus laevis: phylogenetic conservation of the functional domains.
Gene. 1993 Dec 31;137(2):293-7.
PMID: 8299962
Uchida K, Hanai S, Ishikawa K, Ozawa Y, Uchida M, Sugimura T, Miwa M.
Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain.
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3481-5.
PMID: 8475096