Clock Gene in Animal Update: 2009.3.13 Site Map
Clock Gene Homolog
PERIOD CLOCK, NPAS2 ARNTL [BMAL] DEC, (cwo) Id1-4 NF1L3 [E4BP4] (vri)
DBP, (pdp1) NR1D1 [REV-ERB] RORA-C SIRT1-7 CRY, PHR TIM, (timeless)
GSK3 (sgg) CSNK1 CSNK2 BTRC (slmb) FBXL3 FBXL15 (jet)

SIRT family

→ Outlineeng→JPNJPN; → Mutant list

Scientific name Gene GeneID Homologene Blink Protein
Homo sapiens SIRT1 23411 56556 hs_SIRT1 NP_036370
SIRT2 22933 40823 hs_SIRT2 NP_036369
SIRT3 23410 81827 hs_SIRT3 NP_036371
SIRT4 23409 8164 hs_SIRT4 NP_036372
SIRT5 23408 40825 hs_SIRT5 NP_036373
SIRT6 51548 6924 hs_SIRT6 NP_057623
SIRT7 51547 56152 hs_SIRT7 NP_057622
Mus musculus Sirt1 S93759 56556 mm_SIRT1 NP_062786
Sirt2 40823 40823 mm_SIRT2 NP_071877
Sirt3 64384 81827 mm_SIRT3 NP_071878
Sirt4 75387 8164 mm_SIRT4 XP_485674
Sirt5 68346 40825 mm_SIRT5 NP_849179
Sirt6 50721 6924 mm_SIRT6 NP_853617
Sirt7 209011 56152 mm_SIRT7 NP_694696
Gallus gallus SIRT1 423646 56556 gg_SIRT1 NP_001004767
SIRT2 548628 - gg_SIRT2 NP_001017414
SIRT3 422988 81827 gg_SIRT3 XP_420920
SIRT4 416981 8164 gg_SIRT4 XP_415273
SIRT5 420834 40825 gg_SIRT5 XP_418925
SIRT6 428332 6924 gg_SIRT6 NP_001034409
SIRT7 422093 56152 gg_SIRT7 NP_001026277
Xenopus tropicalis sirt1 100145679 - xt_SIRT1 CAL49361
sirt2 UGID:1441410 - - -
sirt3.2 100145681 - xt_SIRT3 NP_001120529
sirt4 733911 - xt_SIRT4 NP_001039093
sirt5 UGID:1675144 - - Xentro_sirt5.txt
sirt6 394980 - xt_SIRT6 NP_989353
sirt7 548532 - xt_SIRT7 NP_001015815
Xenopus laevis LOC100036963 100036963 - xl_SIRT1 NP_001091195
sirtuin2 495688 - xl_SIRT2 NP_001088636
LOC734623 734623 - xl_SIRT3 NP_001089567
LOC414591 414591 - xl_SIRT4 NP_001084634
LOC496346 =MGC81733 496346 - xl_SIRT5 NP_001088966
MGC82564 =LOC100037190 444018 - xl_SIRT6 NP_001085592
LOC495235 495235 - xl_SIRT7 NP_001088383
Danio rerio sirt1 100150700 56556 dr_SIRT1 XP_001923245
sirt2 322309 40823 dr_SIRT2 NP_955890
sirt3 558775 81827 dr_SIRT3 NP_001073643
LOC791628 91628 8164 dr_SIRT4 XP_001330976
sirt5 436878 40825 dr_SIRT5 NP_001002605
sirt6 415161 6924 dr_SIRT6 NP_001002071
sirt7 796135 56152 dr_SIRT7 XP_001336438
Ciona intestinalis sir2-c(sirt1) 778894 - ci_SIRT1 XP_002124792
sir2-e(sirt2) 751591 - ci_SIRT2 XP_002119370
sir2-a(sirt3) 494364 - ci_SIRT3 XP_002127418
sir2-b (sirt4) 778889 - ci_SIRT4 BAE93336
LOC100177952 100177952 - ci_SIRT5 XP_002129772
sir2-d(sirt6) 100170015 - ci_SIRT6 XP_002123765
LOC100185848 100185848 - ci_SIRT7 XP_002121470
Branchiostoma floridae BF_175074(sirt1) 7212523 - bf_SIRT1 XP_002241754
BF_146719(sirt2) 7252219 - bf_SIRT2 XP_002237260
BF_223028(sirt3) 7226234 - bf_SIRT3 XP_002218361
BF_62719(sirt4) 7235947 - bf_SIRT4 XP_002247311
BF_60850(sirt5) 7250289 - bf_SIRT5 XP_002233297
BF_125988(sirt6)= BF_274519 7213850 - bf_SIRT6 XP_002228220
BF_68156(sirt7) 7220221 - bf_SIRT7 XP_002205531
Strongylocentrotus purpuratus LOC591711 591711 - sp_SIRT1 XP_796354
LOC585308 585308 - sp_SIRT2 XP_790234
LOC579834 579834 - sp_SIRT3 XP_785021
LOC589067 589067 - sp_SIRT4 XP_793816
LOC574945 574945 - sp_SIRT5 XP_780446
LOC581906 581906 - sp_SIRT6 XP_786976
LOC762797 762797 - sp_SIRT7 XP_001198553
Apis mellifera LOC411917 411917 - am_SIRT1 XP_395386
LOC409532 409532 - am_SIRT2 XP_393038
LOC551260 551260 - am_SIRT4 XP_623654
LOC552701 552701 - am_SIRT5 XP_625080
LOC412846 412846 - am_SIRT6 XP_396298
LOC413728 413728 - am_SIRT7 XP_397168
Anopheles gambiae AGAP002943 1273019 40823 ag_SIRT2 XP_311957
*discontinued! 1271514 8164 ag_SIRT4 XP_310322
AGAP001458 1281717 6924 ag_SIRT6 XP_321669
AGAP001220 1281949 56152 ag_SIRT7A XP_321936
AGAP001221 3290440 56152 ag_SIRT7B XP_551623
Drosophila melanogaster Sir2 (Sirt1) 34708 56556 dm_SIR2 NP_477351
Sirt2 42414 40823 dm_SIRT2 NP_650880
Sirt4 31480 8164 dm_SIRT4 NP_572241
Sirt6 41254 6924 dm_SIRT6 NP_649990
Sirt7 43433 56152 dm_SIRT7 NP_651664
Caenorhabditis elegans sir-2.1 177924 56556 ce_SIR-2.1 NP_501912
SIR 181455 8164 ce_SIR NP_001024672
Nematostella vectensis v1g136467(sirt1) 5502613 - nv_SIRT1 XP_001623784
v1g228435 (sirt2) 5518876 - nv_SIRT2 XP_001638876
v1g179325(sirt3) 5519780 - nv_SIRT3 XP_001639735
v1g190741 (sirt4) 5507285 - nv_SIRT4 XP_001627929
v1g86891(sirt5) 5519523 - nv_SIRT5 XP_001639425
v1g31928 (sirt6) 5503598 - nv_SIRT6 XP_001624617
v1g176429sirt7 5500391 - nv_SIRT7 XP_001621847
Trichoplax adhaerens TA_26603 (SIRT2) 6754648 - ta_SIRT2A XP_002113435
TA_26227 (SIRT2) 6754463 - ta_SIRT2B*P XP_002113608
TA_52084 (SIRT3) 6749985 - ta_SIRT3A XP_002108771
TA_19190 (SIRT3) 6749986 - ta_SIRT3B XP_002108772
TA_59014 (SIRT4) 6756363 - ta_SIRT4 XP_002114969
TA_24253 (SIRT5) 6753209 - ta_SIRT5 XP_002111996
TA_23343 (SIRT6) 6751492 - ta_SIRT6 XP_002110277
TA_53549 (SIRT7) 6751240 - ta_SIRT7 XP_002109473
Schizosaccharomyces pombe sir2 3361342 56556 ScPo_SIR2 NP_001018840
hst2 2538868 40823 ScPo_HST2 NP_588147
Saccharomyces cerevisiae HST1 854086 56556 SaCe_HST1 NP_014573
HST2 856092 40823 SaCe_HST2 NP_015310
Kluyveromyces lactis KLLA0F11033g 2895121 40823 KlLa_HST2 XP_455583
Ashbya gossypii ABL004Wp 4619035 40825 AsGo_SIRT5 NP_982943
Magnaporthe grisea MGG_02488 2681585 56556 MaGr_SIR2 XP_365786
MGG_14172 5048967 40823 MaGr_HST2 XP_001404080
MGG_10267 2681820 81827 MaGr_SIRT3 XP_366047
MGG_12698 2680071 40825 MaGr_SIRT5 XP_364179
Neurospora crassa NCU04737 3876510 56556 NeCr_SIR2 XP_960372
NCU00523 3879874 40823 NeCr_HST2 XP_963725
NCU05973 3874773 40825 NeCr_SIRT5 XP_958626
NCU03059 3879860 - NeCr_HST4 XP_963711
NCU07624 3878947 56152 NeCr_SIRT XP_962799
Plasmodium falciparum PF13_0152 814122 40825 PlFa_SIRT5 XP_001350011
Arabidopsis thaliana SRT2 830782 8164 ArTh_SRT2 NP_001078550
SRT1 835670 6924 ArTh_SRT1 NP_200387
Oryza sativa Os12g0179800 4351669 8164 OrSa_SRT2 NP_001066310
Os04g0271000 4335342 6924 OrSa_SRT1 NP_001052343
Plant and Fungi genes (green cells) were shown in this site, if the gene was listed in Homologene of animal gene.
Note: Circadian clock function of  Sirt1 was reported in mouse cultured cells(Asher2008, Nakahata2008).
Cladogram of SIRT

Phylogram of SIRT

List of SIRT sequences for ClustalW2 DND file of SIRT for TreeView

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