Clock Gene in Animal Update: 2009.3.13 Site Map
Clock Gene Homolog
PERIOD CLOCK, NPAS2 ARNTL [BMAL] DEC, (cwo) Id1-4 NF1L3 [E4BP4] (vri)
DBP, (pdp1) NR1D1 [REV-ERB] RORA-C SIRT1-7 CRY, PHR TIM, (timeless)
GSK3 (sgg) CSNK1 CSNK2 BTRC (slmb) FBXL3 FBXL15 (jet)

RORA, B, C (RAR-related orphan receptor A-C, NR1F1-3)

→ Outlineeng→JPNJPN; → Mutant list

Scientific name Gene GeneID Homologene Blink Protein
Homo sapiens RORA(Nr1f1) 6095 56594 hs_RORA NP_599023
RORB(Nr1f2) 6096 38250 hs_RORB NP_008845
RORC(Nr1f3) 6097 21051 hs_RORC NP_005051
Mus musculus Rora 19883 56594 mm_RORA NP_038674
Rorb 225998 38250 mm_RORB NP_666207
Rorc 19885 21051 mm_RORC NP_035411
Gallus gallus RORA 415377 56594 gg_RORA XP_413763.2
RORB 395980 38250 gg_RORB NP_990424
Xenopus tropicalis rora 780120 - xt_RORA*P 202321.txt
JGI:385932 (rorb) JGI:385932 - xt_RORB*P 385932.txt
JGI:426953 (rorc) JGI:426953 - xt_RORC*P 426953.txt
Xenopus laevis LOC495242 (rorc)(rorc) 495242 - xl_RORC*P NP_001088389
Danio rerio roraa (rora2) 564951 - dr_RORAA NP_001103637
rorab (rora) 554722 - dr_RORAB NP_957361
rorb 567943 38250 dr_RORB NP_001076325
rorca 559245 117486 dr_RORCA NP_001076288
rorcb 562258 1174864A dr_RORB XP_690743
Ciona intestinalis ror 779001 - ci_ROR NP_001072021
Branchiostoma floridae BF_174225(RORB) 7251791 - bf_ROR XP_002235413
Strongylocentrotus purpuratus LOC579483 579483 - sp_RORA XP_784691
Apis mellifera GB10650(RORB) 408586 - am_Hr46 XP_392128
Anopheles gambiae AGAP009002(RORB) 1279961 38250 ag_Hr46 XP_319750
Drosophila melanogaster Hr46(RORB) 36073 38250 dm_Hr46 NP_788301
Caenorhabditis elegans nhr-23(RORB) 172460 38250 ce_NHR-23 NP_001032971
Nematostella vectensis Not found - - - -
Trichoplax adhaerens Not found - - - -
Note: ROR alpha was involved in circadian behavior of mouse.
Role of ROR beta, gamma and insect homologue in clock is not known in animal model.

Cladogram of NR1D1 and ROR (including human PPAR, RAR)
Phylogram of NR1D1 and ROR (including human PPAR, RAR)
List of NR1D1 and ROR (including human PPAR, RAR) sequences for ClustalW2 DND file of NR1D1 and ROR (including human PPAR, RAR) for TreeView

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