Clock Gene in Animal Update: 2009.3.13 Site Map
Clock Gene Homolog
PERIOD CLOCK, NPAS2 ARNTL [BMAL] DEC, (cwo) Id1-4 NF1L3 [E4BP4] (vri)
DBP, (pdp1) NR1D1 [REV-ERB] RORA-C SIRT1-7 CRY, PHR TIM, (timeless)
GSK3 (sgg) CSNK1 CSNK2 BTRC (slmb) FBXL3 FBXL15 (jet)

NR1D1, NR1D2(REV-ERB-Alpha, BETA)

→ Outlineeng→JPNJPN; → Mutant list

Scientific name Gene GeneID Homologene Blink Protein
Homo sapiens NR1D1 9572 23324 hs_NR1D1 NP_068370
NR1D2 9975 3763 hs_NR1D2 NP_005117
Mus musculus Nr1d1(Rev-erba) 217166 23324 mm_NR1D1 NP_663409
Nr1d2(Rev-erbb) 353187 3763 mm_NR1D2 NP_035714
Gallus gallus NR1D2 396125 3763 gg_NR1D2 NP_990536
Xenopus tropicalis nr1d1 100101679 - xt_NR1D1 NP_001093675
Xenopus laevis MGC82865 444369 - xl_NR1D1 NP_001085940
Danio rerio nr1d1 494487 23324 dr_NR1D1 NP_991292
nr1d2a 402815 - dr_NR1D2A NP_001124064
nr1d2b 30271 3763 dr_NR1D2B NP_571140
nr1d4a 563150 120195 dr_NR1D4A XP_691607
nr1d4b 571948 120195 dr_NR1D4B XP_700687
Ciona intestinalis rev-erb(nr1d2) 778931 - ci_REV-ERB NP_001071962
Branchiostoma floridae BF_67032(nr1d2) 7222206 - bf_NR1D2 NP_002204584
Strongylocentrotus purpuratus LOC756187 756187 - sp_NR1D1 XP_001193835
Apis mellifera GB11364 410309 - am_Eip75 NP_001073579
Anopheles gambiae AGAP012223 1280470 120195 ag_Eip75 XP_320316
Drosophila melanogaster Eip75B 39999 120195 dm_Eip75B NP_730321
Caenorhabditis elegans nhr-85 (nr1d2) 191732 - ce_NHR-85 NP_001021667
Nematostella vectensis Not found - - - -
Trichoplax adhaerens Not found - - - -
NR1D1 (REV-ERB alpha) and NR1D2 (REV-ERB beta) have redundant function in rhythmic expression of ARNTL(Bmal1) (Liu2008).

Cladogram of NR1D1 and ROR (including human PPAR, RAR)
Phylogram of NR1D1 and ROR (including human PPAR, RAR)
List of NR1D1 and ROR (including human PPAR, RAR) sequences for ClustalW2 DND file of NR1D1 and ROR (including human PPAR, RAR) for TreeView
Phylogram of NR super family (human, fly, nematoda) is available in Maglich2001.


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