Clock Gene in Animal Update: 2009.3.13 Site Map
Clock Gene Homolog
PERIOD CLOCK, NPAS2 ARNTL [BMAL] DEC, (cwo) Id1-4 NF1L3 [E4BP4] (vri)
DBP, (pdp1) NR1D1 [REV-ERB] RORA-C SIRT1-7 CRY, PHR TIM, (timeless)
GSK3 (sgg) CSNK1 CSNK2 BTRC (slmb) FBXL3 FBXL15 (jet)

DBP, HLF, TEF, Pdp1

→ Outlineeng→JPNJPN; → Mutant list

Scientific name Gene GeneID Homologene Blink Protein
Homo sapiens DBP 1628 1035 hs_DBP NP_001343
HLF 3131 31074 hs_HLF NP_002117
TEF 7008 31140 hs_TEF NP_003207
Mus musculus Dbp 13170 1035 mm_DBP NP_058670
Hlf 217082 31074 mm_HLF NP_766151
Tef 21685 31140 mm_TEF NP_059072
Gallus gallus HLF 417395 31074 gg_HLF XP_415649
TEF 396342 31140 gg_TEF NP_990713
Xenopus tropicalis JGI:280875 (dbp) 280875 - xt_DBP*P 280875.txt
tef 550073 - xt_TEF NP_001017319
Xenopus laevis tef =LOC494759 379940 - xl_TEF NP_001080248
Danio rerio zgc:153035(hlf) 768192 31074 dr_HLF NP_001070802
LOC557886(hlf) 557886 90607 dr_LOC557886 XP_686132
LOC569109(dbp?hlf?) 569109 - dr_LOC569109 XP_001921786
tef 30674 31140 dr_TEF NP_571475
zgc:112180(tef) 553686 - dr_LOC553686 NP_001018497
Ciona intestinalis tef/hlf 778775 - ci_TEF/HLF NP_001071833
Branchiostoma floridae BF_190083(ces-2?) 7220878 - bf_190083*P XP_002216949
BF_204721(Pdp1) 7224107 - bf_204721*P XP_002207028
BF_230629 (Pdp1)=BF_230569 7250251 - bf_230629*P XP_002233149
Strongylocentrotus purpuratus Hlf 593063 - sp_HLF NP_001123286
LOC761649 =LOC754221 (ces-2 like) 761649 - sp_LOC761649 XP_001192725
LOC580363 (ces-2 like) 580363 - sp_LOC580363 XP_001185862
Apis mellifera GB13981 (Pdp1) 408449 am_PDP1 XP_391997
GB16015(gt like) 725191 - am_GT_like XP_001121066
Anopheles gambiae AGAP006376 1276989 31074 ag_PDP1 XP_001237806
AGAP001880 (gt like) 1281243 - ag_GT_like XP_321187
Drosophila melanogaster Pdp1 45588 31074 dm_PDP1 NP_729297
CG4575(gt like) 31637 - dm_CG4575 NP_572367
CG7786 (ces-2 like) 36802 - dm_CG7786 NP_611101
gt (giant) 31227 50945 dm_GT NP_525049
Caenorhabditis elegans ces-2 173365 - ce_CES-2 NP_493610
F17A9.3(gt like) 178998 - ce_F17A9.3 NP_504576
C48E7.11(NFIL3 like) 172319 - ce_C48E7.11 NP_871835
Nematostella vectensis v1g87565 5519226 - nv_v1g87565 XP_001639072
v1g150375 5497987 - nv_v1g150375 XP_001619763
v1g165267 5514360 - nv_v1g165267 XP_001634510
v1g197394 5521320 - nv_v1g197394 XP_001641008
v1g39846 5521940 - nv_v1g39846 XP_001641694
Trichoplax adhaerens TA_61920 6759104 - ta_61920 XP_002117891
TA_52980 6750413 - ta_52980 XP_002109198
TA_53726 (ces-2 like) 6751321 - ta_CES2-like XP_002109563
Note: Clock function was reported in Drosophila Pdp1.
Triple KO of mouse for Dbp, Hlf and Tef shows normal circadian activity(Gachon2004), so this family was not regarded as clock gene in mammal.
Cladogram of NFIL3, DBP, PDP1
Phylogram of NFIL3, DBP, PDP1
List of NFIL3, DBP, PDP1 sequences for ClustalW2 DND file of NFIL3, DBP, PDP1 for TreeView

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