Clock Gene in Animal Update: 2009.3.17  Site Map
List of clock genes Outline of clock genes Animal model List of animals

Clock Genes in Animal

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Domain,
Function
Gene name

HUGO [Synonym] (fly)
Species  (Place cursor to show comment.Click to taxon tree)
Homo sapiens Mus musculus Gallus gallus Xenopus tropicalis Xenopus laevis Danio rerio Ciona intestinalis Branchiostoma floridae Strongylocentrotus purpuratus Apis mellifera Anopheles gambiae Drosophila melanogaster Caenorhabditis elegans Nematostella vectensis Trichoplax adhaerens
bHLH
PAS
PER (period) 3 3 2 3 2 4 0 1 0 1 1 1 1 0 0
CLOCK, NPAS2 a 2 2 2 2 1 3 0 1 1 1 1 1 0 1 0
ARNTL [BMAL] (cycle) 2 2 2 2 1 3 0 1 1 1 1 1 0 1 0
bHLH
Orange
BHLHE40,41 [DEC1, 2] 2 2 1 2 1 2 0 1b 0 0 0 0 0 0 0
(cwo) 0 0 0 0 0 0 0 0 1 1 1 0 0 0
HLH Id1-4 4 4 4 3 3 5 0 1 1 1 1 1 0 1 0
bZIP NFIL3 [E4BP4] (vrille) 1 1 1 1 1 1 2 1 1 1 1 1 1 0 0
DBP, HLF (Pdp1) c 3 3 2 2 1 5 1 3 3 2 2 4 3 5 3
Nuclear
receptor
NR1D1, 2 [REV-ERB] 2 2 1 1 1 5 1 1 1 1 1 1 1 00
RORA , B, C [NR1F1-3] 3 3 2 3 1 5 1 1 1 1 1 1 1 0 0
SIR2 SIRT1-7  7 7 7 7 7 7 7 7 7 7 4 5 2 7 8
photolyase
FAD bind
CRY d 2 2 2 1 1 5 0 1 1 1 1 0 0 1 0
(cry) e 0 0 0 0 0 0 0 0 1 0 1 1 0 0 0
PHOTOLYASE f 0 0 2 3 3 3 1g 2 1 0 2 2 0 1h 2g
CRY-DASH f 0 0 0 1 1 1 0 0 1 0 0 0 0 1h 0
  (timeless)i 0 0 0 0 0 0 0 0 1 0 1 1 0 0 0
Kinase GSK3 (shaggy) 2 2 1 2 2 4 1 1 1 1 1 1 1 1 1
CSNK1 (dco/dbt) 7 7 4 7 6 8 1j 5 4 3 3 3 3 4 3
CSNK2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1
F-box
(Ubi-ligase)
BTRC [FWD1](slimb) 2 2 2 1 1 2 1 1 1 1 1 1 1 1 1
FBXL3, 21 [overtime, after-hours] 2 2 2 1 1 3 0 1 1 1 0 0 0 0 0
FBXL15 (jetlag) 1 1 1 1 1 1 0 0 1 0 1 1 0 1 0

2 1 0
Numbers in cells indicate the number of homologs found in the species. (ex., Rora, Rorb, Rorc = 3)
3
Purple cells: loss-of-function mutant is arrhythmic and viable.
3
Red cell: Behavioral rhythm was altered in animal model.
3
Yellow cell: clock function was reported in cultured cell.
3
Blue cell: Clock function is unknown or normal behavioral rhythm in animal model.

Gene name was shown basically according human official symbol by HGNC. Synonym was put in brackets: [synonym]. Gene name for Drosophila was put in parentheses: (fly gene).
List of animals and status of genome project

Footnotes
a. NPAS2 was regarded as a paralogue of the CLOCK.
b. The sequence cannot be classified as DEC and cwo.
c. Numbers include giant and ces-2 like sequences.
d. Mammalian type CRY.
e. Insect type CRY.
f. 'Non-clock' family was listed for reference.
g. Bacterial PHR like.
h. Additional four PHR, CRY-DASH like sequences were found.
i. Vertebrate type TIMELESS was classified as timeout and omitted from this list. timeout was found in all animals (→ timeless homolog list).
j. CSNK1A


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