高島 一郎 / Ichiro Takashima

国立研究開発法人 産業技術総合研究所 人間情報研究部門
Tel. 029-861-5563,  Fax. 029-861-5849
筑波大学 人間総合科学研究科 感性認知脳科学専攻

脳型情報処理機構学分野 (連携大学院)




  脳機能イメージング (光学的測定法による,脳の機能的構造の解明)


  • 単離全脳標本を用いた辺縁系皮質の機能構造解析

  • 脳電気刺激によるニューロモジュレーションに関する研究

  • 脳代謝物質のリアルタイム計測

  • 感覚情報の皮質表現/統合処理機構の研究

  • Neurovascular coupling に関する研究

  • 行動下での脳活動 光計測技術の開発

  • Brain Machine Interface 要素技術の研究開発


  • Sato T., Kajiwara R., Takashima I., Iijima T. (2018) Wavelet correlation analysis for quantifying similarities and real-time estimates of information encoded or decoded in single-trial oscillatory brain waves,  Book Chapter "Wavelet theory and its applications", 15-42 [PDF]

  • Nakata M., Nagasaka K., Shimoda M., Takashima I., Yamamoto S. (2018)  Focal brain lesions induced with ultraviolet irradiation,  Sci Rep, 8, 7968 [Abstract]

  • Watanabe Y., Nik-Mohd-Afizan N.A.R., Takashima I. (2017)  Blood-brain barrier derangement after electrical brain stimulationt,  J Neurol Neuromed, 2, 1-5 [Abstract]

  • Nagasaka K., Takashima I., Matsuda K., Higo N. (2017)  Late-onset hypersensitivity after a lesion in the ventral posterolateral nucleus of the thalamus: A macaque model of central post-stroke pain,  Sci Rep, 7, 10316 [Abstract]

  • Nagasaka K., Watanabe Y., Takashima I. (2017)  Topographical projections from the nucleus basalis magnocellularis (Mynert) to the frontal cortex: A voltage-sensitive dye imaging study in rats,  Brain Stim, 10(5), 977-980 [Abstract]

  • Nik-Mohd-Afizan N.A.R., Watanabe Y., Takashima I. (2017)  Safety of anodal transcranial direct current stimulation with respect to blood-brain barrier permeability in the rat,  Curr Neurobiol, 8, 34-39 [Abstract]

  • Kunori N., Takashima I. (2016)  High-order motor cortex in rats receives somatosensory inputs from the primary motor cortex via cortico-cortical pathways,  Eur J Neurosci, 44, 2925-2934 [Abstract]
  • Sato T., Kajiwara R., Takashima I., Iijima T. (2016)  A novel method for quantifying similarities between oscillatory neural responses in wavelet time-frequency power profiles,  Brain Res, 1636, 107-117 [Abstract]
  • Kunori N., Kajiwara R., Takashima I. (2016)  The ventral tegmental area modulates intracortical microstimulation (ICMS)-evoked M1 activity in a time-dependent manner,  Neurosci Lett, 616, 38-42 [Abstract]

  • Kajiwara R., Takashima I. (2015)  Early exposure to urethane anesthesia: effects on neuronal activity in the piriform cortex of the developing brain,  Neurosci Lett, 600, 121-126 [Abstract] 

  • Kunori N., Takashima I. (2015)  A transparent epidural electrode array for use in conjunction with optical imaging,  J Neurosci Methods, 251, 130-137 [Abstract]

  • Ohmae S., Takahashi T., Lu X., Nishimori Y., Kodaka Y., Takashima I., Kitazawa S. (2015)  Decoding the timing and target locations of saccadic eye movements from neuronal activity in macaque oculomotor areas,  J Neural Eng, 12(3) 036014 [Abstract] 

  • Nik-Mohd-Afizan N.A.R., Watanabe Y., Takashima I. (2015)  Effect of the transcranial direct current stimulation on permeability of blood brain barrier in the rat,  Brain Stim, 8(2), 417
  • Kunori N., Kajiwara R., Takashima I. (2014)  Voltage-sensitive dye imaging of primary motor cortex activity produced by ventral tegmental area stimulation,  J Neurosci, 34(26) 8894-8903 [Abstract] [研究成果の 解説ページへ]

  • Yamamoto T., Oishi T., Higo N., Murayama S., Sato A., Takashima I., Sugiyama Y., Nishimura Y., Murata Y., Yoshino-Saito K., Isa T., Kojima T. (2013)  Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery,  PLoS One 8(5) e65701 [Abstract] 

  • 佐藤孝明,廣野順三,松川睦,古殿雄一,梶原利一,高島一郎,川﨑隆史,飯島敏夫 「類似したニオイを識別するための嗅覚の仕組み」,Aroma Research,Vol.15, No.1,3-9 (2013)

  • Kajiwara R., Takashima I. (2010)  Neural circuit analysis using isolated whole brain preparation,  Brain Nerve, 62(3), pp.243-254  [Abstract]

  • Watanabe Y., Kajiwara R., Takashima I. (2009)  Optical imaging of rat prefrontal neuronal activity evoked by stimulation of the ventral tegmental area,  Neuroreport, 20, pp.875-880  [Abstract]

  • Sato T., Hirono J., Hamana H., Ishikawa T., Shimizu A., Takashima I., Kajiwara R., Iijima T. (2008)  Architecture of odor information processing in the olfactory system,  Anat Sci Int, 83, pp.195-206  [Abstract]]

  • Kajiwara R., Tominaga T., Takashima I. (2007)  Olfactory information converges in the amygdaloid cortex via the piriform and entorhinal cortices: observations in the guinea pig isolated whole-brain preparation,  Eur J Neurosci, 25, pp.3648-3658 [Journal Cover Photo]  [Abstract] 

  • Narumi T., Nakamura S., Takashima I., Kakei S., Tsutsui K., Iijima T. (2007)  Impairment of the discrimination of the direction of single-whisker stimulation induced by the lemniscal pathway lesion,  Neurosci Res, 57, pp.579-586  [Abstract]

  • Inase M., Li B.M., Takashima I., Iijima T. (2006)  Cue familiarity is represented in monkey medial prefrontal cortex during visuomotor association learning,  Exp Brain Res., 168, pp.281-286  [Abstract]

  • Takashima I., Kajiwara R., Iijima T. (2005)  Voltage-sensitive dye imaging of intervibrissal fur-evoked activity in the rat somatosensory cortex,  Neurosci Lett, 381, pp.258-263  [Abstract]

  • Inase M., Li B.M., Takashima I., Iijima T. (2003)  Learning-selective changes in activity of the basal ganglia,  In: Graybiel AM, DeLong MR, Kitai ST (eds)  The Basal Ganglia VI.  Kluwer Academic/Plenum Publishers, New York, pp.297-302

  • Biella G.R., Guatkovsky V., Takashima I., Kajiwara R., Iijima T., de Curtis M. (2003)  Olfactory input to the parahippocampal region of the isolated guinea pig brain reveals weak entorhinal-to-perirhinal interactions,  Eur J Neurosci., 18, pp.95-101 [Journal Cover Photo]  [Abstract]

  • Kajiwara R., Takashima I., Mimura Y., Witter M.P., Iijima T. (2003)  Amygdara input promotes spread of excitatory neural activity from perirhinal cortex to the entorhinal-hippocampal circuit,  J Neurophysiol, 89, pp.2176-2184  [Abstract]

  • Takashima I., Kajiwara R., Iijima T. (2002)  Membrane potential microscope for functional brain mapping,  J ITE, 56, pp.476-481  [PDF]

  • Takashima I., Kajiwara R., Iijima T. (2002)  Functional mapping of optically detected neural activity onto a standardized cortical structure of rodent barrels,  IEICE Trans Inf Syst, E85D-1, pp.143-151  [Abstract]

  • Takashima I., Kajiwara R., Iijima T. (2001)  Voltage-sensitive dye versus intrinsic signal optical imaging: Comparison of optically determined functional maps from rat barrel cortex,  Neuroreport, 12, pp.2889-2894  [Abstract]

  • Inase M., Li B.M., Takashima I., Iijima T. (2001)  Pallidal activity is involved in visuomotor association learning in monkeys,  Eur J Neurosci., 14, pp.897-901  [Abstract]

  • Kajiwara R., Takashima I., Murano K., Mimura Y., Iijima T. (2000)  High-speed videography system using a pair of imagers for biological application,  Proc SPIE, 4183, pp.969-977  [PDF]

  • Takashima I., Kajiwara R., Murano K., Iijima T., Morinaka Y., Komobuchi H. (2000)  High-speed, high-resolution epifluorescence imaging system using CCD sensor and digital storage for neurobiological research,  Proc SPIE, 4183, pp.978-989  [PDF]

  • 飯島敏夫,高橋俊光,肖瑞亭,神作憲司,河野憲二,高島一郎 「fMRIの基礎と活用上の注意点」, 認知神経科学学会誌,Vol.2,No.2, pp.112-117 (2000)

  • Otsu Y., Maru E., Ohata H., Takashima I., Kajiwara R., Iijima T. (2000)  Optical recording study of granule cell activities in the hippocampal dentate gyrus of kainate-treated rats,  J Neurophysiol, 83, pp.2421-2430  [Abstract] 

  • Takashima I., Ichikawa M., Iijima T. (1999)  High-speed CCD imaging system for monitoring neural activity in vivo and in vitro, using a voltage-sensitive dye,  J Neurosci Methods, 91, pp.147-159  [Abstract]

  • de Curtis M., Takashima I., Iijima T. (1999)  Optical recording of cortical activity after in vitro perfusion of cerebral arteries with a voltage-sensitive dye,  Brain Res, 837, pp.314-319  [Abstract]

  • 高島一郎,梶原利一,飯島敏夫 「CCDを用いたリアルタイム神経活動イメージングシステム」,電子技術総合研究所 彙報,Vol.63,pp.11-25 (1999)  [PDF]

  • 高島一郎,佐藤孝明,梶原利一,飯島敏夫 「モルモット単離脳標本への光計測法の適用」,電子技術総合研究所 彙報,Vol.63,pp.27-36 (1999)  [PDF]

  • 飯島敏夫,高島一郎,稲瀬正彦 「光計測法による脳活動ダイナミクスのイメージング」,CLINICAL NEUROSCIENCE,Vol.17,pp.10-11,中外医学社 (1999)

  • 飯島敏夫,稲瀬正彦,高島一郎,梶原利一,他 「膜電位感受性色素による脳活動リアルタイムイメージング」,脳の科学,pp.51-58,星和書店 (1998))

  • Iijima T., Takashima I., Inase M., et al. (1998)  Real-time optical imaging provides dynamic map of brain activity, Proc ICONIP, pp.329-332
  • 飯島敏夫,市川道教,高島一郎,秋山修二 「海馬-嗅内野系神経回路活動の光学的計測」,総合臨床,Vol.46,pp.21-27,永井書店 (1997)

  • 飯島敏夫,市川道教,高島一郎,梶原利一 「神経興奮を見る」,蛋白質・核酸・酵素,Vol.42,pp.1100-1105,共立出版 (1997)

  • 飯島敏夫,市川道教,高島一郎,松本元 「光計測法による高次神経系の機能的構造解析」,生物物理学会誌,Vol.34,pp.43-46 (1994)

  • 飯島敏夫,高島一郎 「光計測法による大脳,体性感覚野の時・空間パターン解析」,実験医学,Vol.12,pp.182-187,羊土社 (1994)

  • Takashima I., Ikezaki M. (1991)  An expanded spanning-tree protocol for home-oriented network management,  IEEE Trans on Cons Electron, 37, pp.379-387  [Abstract]

  • Okui S., Takashima I. (1984)  Some properties of the function Zm(x,y;k) =∬exp (-x2-y2) Im-1(2kxy) (xy)m dyxy, Res Rep, Natl Inst of Tech, Suzuka Col, 17, pp.55-65


  • Society for Neuroscience (SFN)

  • Japan Neuroscience Society (JNSS)

  • The Society of Instrument and Control Engineers (SICE)

  • The Institute of Electronics, Information and Communication Engineers (IEICE)


最終更新日 : 2018/11/28