産総研

Takemura's Homepage

last updated 2024.4.2
写真
Aya Takemura
National Institute of Advanced Industrial Science and Technology (AIST)
Human Informatics and Interaction Research Institute
Neurorehabilitation Research Group　Group Leader
1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan
TEL：050-3521-0027
E-mail：a.takemura(@)aist.go.jp
Education
  • 1990. 4 - 1994. 3 College of Biological Sciences, University of Tsukuba, Ibaraki, Japan
  • 1994. 4 - 1996. 3 Master's Program Graduate School of Medical Sciences, University of Tsukuba, Ibaraki, Japan
  • 1996. 4 - 2000. 3 Graduate School of Medicine, University of Tsukuba, Ibaraki, Japan
  • 　　　　　　　　　 Ph. D.
Positions
  • 1997. 4 - 2000. 3　Research Fellowship for Young Scientists DC1
  • 2000. 4 - 2001. 3　CREST Postdoc
  • 2001. 4 - 2007. 9　Researcher, System Neuroscience Group, Neuroscience Institute,
  • 　　　　　　　　　 　　　　　　　　　 National Institute of Advanced Industrial Science and Technology (AIST)
  • 2007.10 - 2010. 3　Senior Researcher, System Neuroscience Group, Neuroscience Institute,
  • 　　　　　　　　　 　　　　　　　　　 National Institute of Advanced Industrial Science and Technology (AIST)
  • 2010. 4 - 2015. 3　Senior Researcher, System Neuroscience Group, Human Technology Institute,
  • 　　　　　　　　　 　　　　　　　　　 National Institute of Advanced Industrial Science and Technology (AIST)
  • 2015. 4 - 2018.10　Senior Researcher, System Neuroscience Group, Human informatics Institute,
  • 　　　　　　　　　 　　　　　　　　　 National Institute of Advanced Industrial Science and Technology (AIST)
  • 2018.11 - 2021. 3　Group Leader, System Neuroscience Group, Human informatics Institute,
  • 　　　　　　　　　 　　　　　　　　　 National Institute of Advanced Industrial Science and Technology (AIST)
  • 2021. 4 - 2022. 3　Senior Researcher, Neurorehabilitation Research Group,
  • 　　　　　　　　　 　　　　　　　　　 Human Informatics and Interaction Research Institute,
  • 　　　　　　　　　 　　　　　　　　　 National Institute of Advanced Industrial Science and Technology (AIST)
  • 2022. 4 -　　　　　Group Leader, Neurorehabilitation Research Group,
  • 　　　　　　　　　 　　　　　　　　　 Human Informatics and Interaction Research Institute,
  • 　　　　　　　　　 　　　　　　　　　 National Institute of Advanced Industrial Science and Technology (AIST)
Research

Synopsis of Research

Motor learning
To adapt to variable environments, humans regulate their behavior by modulating gains in sensory-to-motor processing. In our lab, we conduct research physiological experimentals and mathematical modeling on a simple eye movement, the ocular following response (OFR), in monkeys to study the neuronal basis of adaptive motor learning in the visuomotor processing stream.

Stabilization of the eyes and hands
Visual and motor acuity is severely impaired if an object of interest moves excessively on the retina. Sensori-motor responses with ultra-short latencies, ‘ocular following response (OFR)’ and 'manual following response (MFR)' which tracking visual motion play a significant role in ameliorating such problems.

Pathophysiological mechanisms of psychiatric disorders
Using a non-human primate model, we are trying to explore the "malfunction in the cognitive function mechanism" for the schizophrenia.

Publications

Macaque monkeys show reversed ocular following responses to two-frame-motion stimulus presented with inter-stimulus intervals. Takemura A, Matsumoto J, Hashimoto R, Kawano K, Miura K. J Comput Neurosci. 2020. doi: 10.1007/s10827-020-00756-3. Online ahead of print., 2020/07
Model of optokinetic responses involving two different visual motion processing pathways. Miura K, Takemura A, Taki M, Kawano K. Progress Brain Research, 248:329-340, 2019/06
Neural Activity in the Dorsal Medial Superior Temporal Area of Monkeys Represents Retinal Error during Adaptive Motor Learning. Takemura A, Ofuji T, Miura K, Kawano K. Scientific Reports, 7, 40939; doi: 10.1038/srep40939, 2017/01
A Widely Applicable Real-time Mono/Binocular Eye Tracking System Using a High Frame-Rate Digital Camera. Matsuda K, Nagami E, Sugase-Miyamoto Y, Takemura A, Kawano K. Human-Computer Interaction. User Interface Design, Development and Multimodality 19th International Conference, HCI International 2017, Vancouver, BC, Canada, July 9-14, 2017, Proceedings, Part I，593-608, 2017/07
MST neurons code for visual motion in space independent of pursuit eye movements，Inaba N, Shinomoto S, Yamane S, Takemura A, Kawano K. J of Neurophysiol., 97, 3473-3483, 2007/05
Deficits in short-latency tracking eye movements after chemical lesions in monkey cortical areas MT and MST. Takemura A, Murata Y, Kawano K, Miles FA. J of Neurosci. 27:529-41, 2007/01
Neuronal Responses in MST Reflect the Post-Saccadic Enhancement of Short-Latency Ocular Following Responses，Takemura A, Kawano K. Exp Brain Res.，173-1，174-179, 2006/06
Ocular tracking of moving targets: effects of perturbing the background，Kodaka Y, Miura K, Suehiro K, Takemura A, Kawano K. J of Neurophysiol.，91(6)，2474-2483, 2004/06
Cerebellar Plasticity and the Ocular Following Response，Yamamoto K, Kobayashi Y, Takemura A, Kawano K, Kawato M. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES，978，439-454, 2002/12
Population Coding of Vergence Eye Movements in Cortical Area MST，Takemura A, Kawano K, C. Quaia, F. A. Miles. Levels of Perception, 257-270, 2002/07
Visually driven eye movements elicited at ultra-short latency are severely impaired by MST lesions，Takemura A, Inoue Y, Kawano K. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES，956, 456-459, 2002/04
Computational studies on acquisition and adaptation of ocular following responses based on cerebellar synaptic plasticity. Yamamoto K, Kobayashi Y, Takemura A, Kawano K, Kawato M. J of Neurophysiol. 87(3):1554-71, 2002/03
Sensory-to-motor processing of the ocular-following response，Takemura A, Kawano K. NEUROSCIENCE RESEARCH，43-3，pp.201-206, 2002/07
Population Coding in Cortical Area MST，Takemura A, Kawano K, C. Quaia, F. A. Miles. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES，956，284-296, 2002/04
Computational studies on acquisition and adaptation of ocular following responses based on cerebellar synaptic plasticity，Yamamoto K, Kobayashi Y, Takemura A, Kawano K, Kawato M. J of Neurophysiol.，87，1554-1571, 2002/03
Change in neuronal firing patterns in the process of motor command generation for the ocular following response. Takemura A, Inoue Y, Gomi H, Kawato M, Kawano K. J Neurophysiol. 86(4):1750-63, 2001/10
Single-Unit Activity in Cortical Area MST Associated With Disparity-Vergence Eye Movements:Evidence for Populating Coding， Takemura A, Inoue Y, Kawano K, Quaia C, Miles F. A. J of Neurophysiol.，85，2245-2266, 2001/04
The effect of disparity on the very earliest ocular following responses and the initial neuronal activity in monkey cortical area MST. Takemura A, Inoue Y, Kawano K. Neuroscience Res.，38，pp.93-101, 2000/09
Role of the pretectal nucleus of the optic tract in short-latency ocular following responses in monkeys. Inoue Y, Takemura A, Kawano K, Mustari M. J. Exp Brain Res. 131(3):269-81, 2000/04
Effects of smooth pursuit eye movement on ocular responses to sudden background motion in humans，Suehiro K, Miura K, Kodaka Y, Inoue Y, Takemura A, Kawano K. Neuroscience Research，35-，pp.329-338, 1999/09
The Role of MST Neurons During Ocular Tracking in 3D Space，Kawano K, Inoue Y, Takemura A, Kodaka Y, F. A. MiIes. International Review of Neurobiology，44: 49-63，1999/04
Short-latency vergence eye movements elicited by looming step in monkeys，Inoue Y, Takemura A, Suehiro　K, Kodaka Y, Kawano K. Neurosciece Research，Vol. 32，185-188, 1998/12
Temporal Firing Patterns of Purkinje Cells in the Cerebellar Ventral Paraflocculus During Ocular Following Responses in Monkeys I. Simple Spikes，Gomi H, Shidara M, Takemura A, Inoue Y, Kawano K, Kawato M. J of Neurophysiol.，Vol. 80，818-831, 1998/08
Temporal Firing Patterns of Purkinje Cells in the Cerebellar Ventral Paraflocculus During Ocular Following Responses in monkeys.II. Complex spikes，Kobayashi Y, Kawano K, Takemura A, Inoue Y, Kitama T, Gomi H, Kawato M. J of Neurophysiol.，80，832-848, 1998/08
Dependence of short-latency ocular following and associated activity in the medial superior temporal area (MST) on ocular vergence.，Inoue Y, Takemura A, Kawano K, Kitama T, F. A. Miles. Exp Brain Res，vol.121，135-144, 1998/04
A mathematical model that reproduces vertical ocular following responses from visual stimuli by reproducing the simple spike firing frequcncy of Purkinje cells in the cerebelium.，Yamamoto K, Kobayashi Y, Takemura A, Kawano K, Kawato M. Neuroscience Research，Vol. 29，161-168, 1997/10
A cortically mediated visual stabilization mechanism with ultrashort latency in primates.，Kawano K, Inoue Y, Takemura A, Kitama T, F. A. Miles. Parietal Lobe Contributions to Orientation in 3D space，25，185-199, 1997/05
Visual Inputs to Cerebellar Ventral Paraflocculus During Ocular Fo1lowint Responses，Kawano K, Takemura A, Inoue Y, Kitama T, Kobayashi Y, Mustari M. J. Progress in Brain Research，vol. 112, 415-422， 1996/12.
Inverse-Dynamics Representation of Eye Movements by Cerebellar Purkinje Cell Activity During Short-Latency Ocular Folowing Responses，Kawano K, Shidara M, Takemura A, Inoue Y, Gomi H, Kawato M. Annals of the New York Academy of Sciences，vol. 781 314-321，1996/11
Effect of Disparity in the Peripheral Field on Short-Latency Ocular Following Responses，Kawano K, Inoue Y, Takemura A, F. A. Miles. Visual Neurosci.，11，（4）833-837, 1994/08