産業技術総合研究所
生物機能工学研究部門
生物時計研究グループ
花井修次
| Minamoto T, Hanai S, Kadota K, Oishi K, Matsumae H, Fujie M, Azumi K, Satoh N, Satake M, Ishida N. Circadian clock in Ciona intestinalis revealed by microarray analysis and oxygen consumption. J Biochem. 2009 Oct 25. PMID: 19855119 |
| Hanai S, Ishida N. Entrainment of Drosophila circadian clock to green and yellow light by Rh1, Rh5, Rh6 and CRY. Neuroreport. 2009 May 27;20(8):755-8. PMID: 19398933 |
| サイエンス最前線：研究者たちの素顔／４ 体内時計と光の関係 毎日新聞 茨城 2008.11.19 |
| Hanai S, Hamasaka Y, Ishida N. Circadian entrainment to red light in Drosophila: requirement of Rh1 and Rh6 Neuroreport.2008 Sep 17;19(14):1441-4. PMID: 18766027 |
| Onishi
Y, Hanai S, Ohno T, Hara Y, Ishida N. Rhythmic SAF-A binding underlies circadian transcription of the Bmal1 gene. Mol Cell Biol. 2008 May;28(10):3477-88. Epub 2008 Mar 10. PMID: 18332112 |
| 時間生物学事典 「血中ホルモン」朝倉書店 |
| きちんとわかる時計遺伝子「時計遺伝子の進化とモデル生物」白日社 |
| Nitta
T, Tanaka M, Sun B, Sugihara E, Kimura M, Kamada Y, Takahashi H, Hanai
S, Jiang SW, Fujisawa J, Miwa M. Reduction of human T-cell leukemia virus type-1 infection in mice lacking nuclear factor-kappaB-inducing kinase. Cancer Sci. 2008 May;99(5):872-8. Epub 2008 Feb 27. PMID: 18312467 |
| 第７回産総研サイエンスカフェ「体内時計のはなし」2007年12月20日 |
| "From Clock Genes to Drug Discovery for Sleep Rhythm Disorder" Hanai S and Ishida N International Symposium on Advances in Neurosciences |
| Kanai
M, Hanashiro K, Kim SH, Hanai S, Boulares AH, Miwa M, Fukasawa K. Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation. Nat Cell Biol. 2007 Oct;9(10):1175-83. Epub 2007 Sep 23. PMID: 17891139 |
| Honjo S, Srivatanakul P,
Sriplung H, Kikukawa H, Hanai S,
Uchida K, Todoroki T, Jedpiyawongse A, Kittiwatanachot P, Sripa B,
Deerasamee S, Miwa M. Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand. Int J Cancer. 2005 Dec 10;117(5):854-60. PMID: 15957169 |
| タンパク質科学イラストレイテッド 第３章７ポリADP-リボシル化 |
| Watcharin
Loilome, Puangrat Yongvanit, Chaisiri Wongkham, Nisana Tepsiri, Banchob
Sripa, Paiboon Sithithaworn, Shuji HANAI,
Masanao MIWA. Altered Gene Expression in Opisthorchis viverrini-Associated Cholangiocarcinoma in Hamster Model Molecular Carcinogenesis.2006 Mar 21 PMID: 16550611. |
| 三輪正
直、金居正幸、杉原英志、大橋紗矢香、野木康子、花井修次. ポリ-ADP-リボシル化による細胞機能、特に中心体と神経細胞機能の調節について ビタミン, vol. 78: pp. 337-346, 2004. 7 |
| 三輪正
直、金居正幸、花井修次 ポリADPリボシル化研究の新展開, 実験 医学2004年６月号. |
| Hanai S, Masuo Y,
Shirai H, Oishi K, Saida K, Ishida N. Differential circadian expression of endothelin-1 mRNA in the rat suprachiasmatic nucleus and peripheral tissues. Neurosci Lett. 2005 Mar 22;377(1):65-8. Epub 2004 Dec 22. PMID: 15722189 |
| Kobayashi H, Oishi
K, Hanai S, Ishida N. Effect of feeding on peripheral circadian rhythms and behaviour in mammals. Genes Cells. 2004 Sep;9(9):857-64. PMID: 15330862 |
| Hanai, S.,
Nitta, T., Shoda, M., Tanaka, M., Iso, N., Mizoguchi, I., Yashiki, S.,
Sonoda, S., Hasegawa, Y., Nagasawa T., and Masanao Miwa Integration of human T-cell leukemia virus type 1 in genes of leukemia cells of patients with adult T-cell leukemia Cancer Sci. 2004 Apr;95(4):306-10. PMID: 15072587 |
| Hanai S,
Kanai M, Ohashi S, Okamoto K, Yamada M, Takahashi H, Miwa M. Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):82-6. Epub 2003 Dec 15. PMID: 14676324 |
| Nitta
T, Tanaka M, Sun B, Hanai S,
Miwa M. The genetic background as a determinant of human T-cell leukemia virus type 1 proviral load. Biochem Biophys Res Commun. 2003 Sep 12;309(1):161-5. PMID: 12943677 |
| Ohashi
S, Kanai M, Hanai S,
Uchiumi F, Maruta H, Tanuma S, Miwa M. Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells. Biochem Biophys Res Commun. 2003 Aug 8;307(4):915-21. PMID: 12878198 |
| Sun
B, Nitta T, Shoda M, Tanaka M, Hanai S,
Hoshino H, Miwa M. Cell-free human T-cell leukemia virus type 1 binds to, and efficiently enters mouse cells. Jpn J Cancer Res. 2002 Jul;93(7):760-6. Erratum in: Jpn J Cancer Res. 2002 Aug;93(8):952. PMID: 12149141 |
| Uchida
M, Hanai S,
Uematsu N, Sawamoto K, Okano H, Miwa M, Uchida K. Overexpression of poly(ADP-ribose) polymerase disrupts organization of cytoskeletal F-actin and tissue polarity in Drosophila. J Biol Chem. 2002 Feb 22;277(8):6696-702. Epub 2001 Dec 13. PMID: 11744702 |
| Uchida
M, Hanai S,
Uematsu N, Sawamoto K, Okano H, Miwa M, Uchida K. Genetic and functional analysis of PARP, a DNA strand break-binding enzyme. Mutat Res. 2001 Jun 2;477(1-2):89-96. PMID: 11376690 |
| Tanaka
M, Sun B, Fang J, Nitta T, Yoshida T, Kohtoh S, Kikukawa H, Hanai S,
Uchida K, Miwa M. Human T-cell leukemia virus type 1 (HTLV-1) infection of mice: proliferation of cell clones with integrated HTLV-1 provirus in lymphoid organs. J Virol. 2001 May;75(9):4420-3. PMID: 11287593 |
| Kanai
M, Uchida M, Hanai S,
Uematsu N, Uchida K, Miwa M. Poly(ADP-ribose) polymerase localizes to the centrosomes and chromosomes. Biochem Biophys Res Commun. 2000 Nov 19;278(2):385-9. PMID: 11097846 |
| Miwa
M, Hanai S,
Poltronieri P, Uchida M, Uchida K. Functional analysis of poly(ADP-ribose) polymerase in Drosophila melanogaster. Mol Cell Biochem. 1999 Mar;193(1-2):103-7. PMID: 10331645 |
| Koyama
Y, Katagiri S, Hanai S,
Uchida K, Miwa M. Poly(ADP-ribose) polymerase interacts with novel Drosophila ribosomal proteins, L22 and l23a, with unique histone-like amino-terminal extensions. Gene. 1999 Jan 21;226(2):339-45. PMID: 9931508 |
| Hanai S,
Uchida M, Kobayashi S, Miwa M, Uchida K. Genomic organization of Drosophila poly(ADP-ribose) polymerase and distribution of its mRNA during development. J Biol Chem. 1998 May 8;273(19):11881-6. PMID: 9565614 |
| Poltronieri
P, Yokota T, Koyama Y, Hanai S,
Uchida K, Miwa M. PARP cleavage in the apoptotic pathway in S2 cells from Drosophila melanogaster. Biochem Cell Biol. 1997;75(4):445-9. PMID: 9493967 |
| Yoshida S, Todoroki
T, Ichikawa Y, Hanai S,
Suzuki H, Hori M, Fukao K, Miwa M, Uchida K. Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers. Cancer Res. 1995 Jul 1;55(13):2756-60. PMID: 7796400 |
| Miwa M, Hanai S,
Masuda H, Koyama Y, Hayashi T, Yoshida Y, Poltronieri P, Maeshima K,
Kobayashi S, Okada M, Uchida K. Analysis of biological function of poly(ADP-ribosyl)ation in Drosophila melanogaster. Biochimie. 1995;77(6):466-71. Review. PMID: 7578431 |
| Uchida K, Uchida M, Hanai S,
Ozawa Y, Ami Y, Kushida S, Miwa M. Isolation of the poly(ADP-ribose) polymerase-encoding cDNA from Xenopus laevis: phylogenetic conservation of the functional domains. Gene. 1993 Dec 31;137(2):293-7. PMID: 8299962 |
| Uchida K, Hanai S,
Ishikawa K, Ozawa Y, Uchida M, Sugimura T, Miwa M. Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3481-5. PMID: 8475096 |