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| 25.Jun | 26.Jun | 27.Jun | 28.Jun | |||
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8:55〜9:00 | Opening remarks | ||||
| Session 1-1: N-Glycan Chairs: A. Kobata, M. Pierce (9:00~10:15) Chairs: K. Suzuki, J. Marth (10:30~11:50) | Session 2-1: Differentiation and Development Chairs: T. Muramatsu, P. Stanley (9:00~10:10) Chairs: T. Endo, J. Gu (10:25~11:10) | Session 3-1: Mass Spectrometry Chairs: P. Rudd, H. Narimatsu | ||||
| 9:00〜9:25 | William Lennarz: A Key Enzyme in Protein N-Glycosylation: Oligosaccharyl Transferase | 9:00〜9:25 | Pamela Stanley: Regulation of Notch1 signaling by the O-fucose glycan in the ligand binding domain | 9:00〜9:15 | Yoshinori Furukawa: NEDO project for glycotechnology: the past, the present and the future | |
| 9:25〜9:50 | Naoyuki Taniguchi: Significance of core fucosylation in TGF-β and epidermal growth factor receptor-mediated intracellular signalings: lessons from gene target mice | 9:25〜9:50 | Tetsuya Okajima: Requirement of O-Fucosyltransferases for Developmental Processes | 9:15〜9:40 | Michael Mormann: Application of high resolution fourier-transform ion cyclotron resonance mass spectrometry to glycoproteomics | |
| 9:50〜10:15 | Jamey Marth: Mammalian protein glycosylation in cellular mechanisms of health and disease | 9:50〜10:00 | Takashi Sato: Molecular cloning and characterization of a novel human β1,3-GLUCOSYLTRANSFERASE, β3GLC-T, which is located at the endoplasmic reticulum and glucosylates 0-linked fucosylglycan on thrombospondin type 1 repeat domain | 9:40〜10:05 | Kay-Hooi Khoo: Mass spectrometry analysis in delineating the occurrence and biosynthesis of branched, extended type 1 chain | |
| 10:15〜10:30 | Coffee Break | 10:00〜10:10 | K. Kozma: Identification of a UDP-Glucose glucosyltransferase that modifies fucosylated thrombospondin type 1 repeats | 10:05〜10:15 | Akihiko Kameyama: A system for intelligent identification of oligosaccharides using observed and simulated MSn spectral libraries | |
18:00〜20:00 poster |
10:30〜10:55 | James Dennis: Mgat5 Regulates Glucose Metabolism and Promotes Stem Cell Renewal | 10:10〜10:25 | Coffee Break | 10:15〜10:30 | Coffee Break |
| 10:55〜11:20 | Iain Wilson: N-Glycosylation Pathways in Caenorhabditis and Drosophila: What Can We Learn from Model Organisms? | 10:25〜10:50 | Michael Pierce: Inhibition of EGF Receptor Signaling by Expression of GnT-Va-Specific siRNA in Human Breast Carcinoma Cells | Session 3-2: Bioinformatics Chairs: T. Kawasaki, R. Oriol | ||
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11:20〜11:35 | Akira Togayachi: Analysis of mice lacking β-1,3-N-acetylglucosaminyltransferase 2 which synthesize polylactosamine chain | 10:50〜11:00 | Jianguo Gu: Cell-cell interaction-dependent regulation of N-acetylglucosaminyltransferase III and the bisected N-glycans in GE11 epithelial cells: involvement of E-cadherin-mediated cell adhesion | 10:30〜10:55 | Rafael Oriol: Phylogeny of the 4 glycosyltransferases involved in the synthesis of the linkage region of GAG |
| 11:35〜11:50 | Shogo Oka: Function and regulation of the HNK-1 carbohydrate in the nervous system | 11:00〜11:10 | Masanori Sakaguchi: The mechanisms of Galectin-1 in promoting proliferation of adult neural stem cells | 10:55〜11:20 | Bernard Henrissat: CAZy: the carbohydrate-active enzyme database | |
| 11:20〜11:45 | Naruya Saitou: Relic of Ancient Recombinations in Gibbon ABO Blood Group Genes Suggests Transspecific Polymorphism | |||||
| 11:50〜12:50 | Poster Session | 11:10〜12:10 | Poster Session | 11:45〜12:45 | Poster Session | |
| 12:30〜13:30 | Lunch | 12:00〜13:30 | Lunch (AIST TOUR) | 12:10〜13:30 | Lunch | |
| Session 1-2: Glycolipids Chairs: S-I. Hakomori, C-H. Kim | Session 2-2: GAG Chairs: K. Kimata, K. Sugahara | Session 3-3: Glycotechnology Chairs: Y. Jigami, K-H. Khoo (13:00~14:40) Chairs: H. Leffler, J. Hirabayashi (14:55~16:05) | ||||
| 13:30〜13:55 | Koichi Furukawa: Regulation of biosignals in cancer cells with glycosphingolipids | 13:30〜13:55 | Kazuyuki Sugahara: Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum: spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases | 13:30〜13:55 | James Paulson: Chemo-Enzymatic Synthesis of High Affinity Analogs of Siglec Ligands | |
| 13:55〜14:20 | Cheorl-Ho Kim: Transcriptional Regulation of the Human GD3 Synthase Gene Expression by Transcription Factor of NF-κB in Fas-Induced Jurkat T Cells | 13:55〜14:20 | Hideto Watanabe: Chondroitin Sulfate N-Acetylgalactosaminyltransferase-1 Plays a Critical Role in Chondrotin Sulfate Synthesis in Cartilage | 13:55〜14:20 | Warren Wakarchuk: Sialyltransferases from Campylobacter jejuni: Update on the Structure and Function of Cst-I and Cst-II | |
| 14:20〜14:30 | X.Q. Wang: Ligand binding to Lewis (Le)X and sialyl-LeX moieties of EGFR promotes EGFR signaling and is blocked by ganglioside GM3 | 14:20〜14:45 | Kenji Kadomatsu: N-acetylglucosamine 6-O-sulfotransferase-1 is required for brain keratan sulfate biosynthesis and glial scar formation after brain injury | 14:20〜14:30 | Cecilia P. C. Chiu: Structural analysis of the α-2,3-sialyltransferase Cst-I from campylobacter jejuni in both the apo and substrate-analogue bound forms | |
| 14:30〜14:45 | Coffee Break | 14:45〜15:00 | Coffee Break | 14:30〜14:40 | Yasuhiro Kajihara: Insight into activation mechanism of CMP-Neu5Ac by sialyltransferase | |
| Session 1-3: O-Glｙcans Chairs: Y. Nagai, R. Cummings | Session 2-3: Disease-related Glycosylation Chairs: A. Suzuki, G. Hart | 14:40〜14:55 | Coffee Break | |||
| 14:45〜15:10 | Gerald W. Hart: O-GlcNAc Transferase: Complex Regulation & Roles in Cellular Metabolism | 15:00〜15:25 | Richard Cummings: Central Role of T-Synthase in O-Glycan Biosynthesis and its Regulation by the Chaperone Cosmc | 14:55〜15:20 | Jun Hirabayashi: Development of lectin-based glycotechnology and its application | |
| 15:10〜15:35 | Tatsuro Irimura: Protective roles of a Galactose-Type C-Type Lectin CD301a/MGL1 Revealed by Pathogenic Models Applied to the Gene Deficient Mice | 15:25〜15:50 | Thierry Hennet:Glycosylation Disorders: Filling the Gaps in the Lipid-Linked Oligosaccharide Biosynthesis Pathway | 15:20〜15:45 | Shoko Nishihara: Functional Analyses of Glycosyltransferases, Sulfotransferases and Transporters by Using RNAi Flies | |
| 15:35〜16:00 | Akemi Suzuki:Kindey Proximal Tubule Cell-Specific Regulation of Core 2 GnT in Mice | 15:50〜16:15 | Tamao Endo: Initiation of Protein O-Mannosylation and Walker-Warburg Syndrome | 15:45〜15:55 | Jerka Dumic: The expression of GALECTIN-3 in activated monocyte-like cells is affected by non-steroidal anti-inflammatory drugs (NSAIDs) | |
| 16:00〜16:25 | Henrik Clausen: Deciphering the Role of Mucin-Type O-Glycosylation for Sorting and Secretion | 16:15〜16:30 | Coffee Break | 15:55〜16:05 | Luke Alderwick: Identification of a novel arabinofuranosyl transferase(AFTA) involved in cell wall arabinan biosynthesis in mycbacterium tuberculosis | |
| 16:25〜16:40 | Coffee Break | Session 2-4: Structural Glycobiology Chairs: P. Qasba, S. Wakatsuki | 16:05〜16:20 | Coffee Break | ||
| Session１-4: Cancer Chairs: K. Furukawa, M. Fukuda (16:40~17:55) Chairs: T. Irimura, P. Delannoy (18:10~19:20) | 16:30〜16:55 | Hakon Leffler: Galectin specificity for natural glycoconjugatges and artificial inhibitors | Session 3-4: Biomarker Chairs: N. Taniguchi, J. Paulson | |||
| 16:40〜17:05 | Minoru Fukuda: 6-Sulfo Sialyl Lewis X on Both O- and N-Glycans Play Critical Roles as L-Selectin Ligands | 16:55〜17:20 | Souichi Wakatsuki: Synchrotron X-ray sheds light on protein glycosylation and carbohydrate recognition in protein transport | 16:20〜16:45 | Jorge Filmus: Glypican-3 Stimulates the Canonical Wnt Signaling Pathway in Hepatocellular Carcinoma, and Inhibits Hedgehog Activity in the Embryo | |
| 17:05〜17:30 | Katsuko Yamashita: Structures and functions of CEA glycans in colon cancer | 17:20〜17:45 | Boopathy Ramakrishnan: Structure and function studies on β1,4-galactosyltransferase-I reveal role of two flexible loops in the catalytic function of the enzyme and its structural and functional similarities to polypeptide α-N-Acetylgalactosaminyltransferase | 16:45〜17:10 | Pauline Rudd: New strategies for cancer diagnostics | |
| 17:30〜17:55 | Phillippe Delannoy: The sialytransferase family: molecular genetic analysis, specificity and role in cancer progression | 17:45〜17:55 | Tomomi Kubota: Structure and substrate specificity of human pp-GalNAc-T10 | 17:10〜17:35 | Eiji Miyoshi: Fucosylated haptoglobin is a novel marker for pancreatic cancer: a detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation | |
| 17:55〜18:10 | Coffee Break | 19:00 〜21:00 Symposium Dinner | 17:35〜17:45 | Sinobu Kitadume: Plasma sialyltransferase:its formation mechanism and application to hepatitis diagnosis | ||
| 18:10〜18:35 | Koichi Honke: Control of cancer metastasis by remodeling of carbohydrate chains | 17:45〜18:05 | Ken Kitajima: Discovery of polysialic acid in microglia. expression changes of α2,8-Sialyltransferases during activation of a mouse microglia cell line | |||
| 18:35〜19:00 | Janxin Gu: Study on the Function and Transcription Regulation of β1,4-Galactosyltransferase (GalT) V in Glioma | Business Meeting | ||||
| 19:00〜19:10 | Yuki Kawamura: Therapeutic potential of gene transfer of a glycosyltransferase using adenoviral vector to prevent cancer metastasis | |||||
| 19:10〜19:20 | Fabio Dall'Olio: Biosynthesys of the Sda determinant by β1,4 N-acetylgalactosaminyltransferase in normal and cancer colon: relationship with sialyl lewis X expression | |||||
Invited Speakers (Tentative)
| Clausen, Henrik | (University of Copenhagen, Denmark) |
| Cummings, Richard D. | (University of Oklahoma, USA) |
| Delannoy, Philippe | (University of Lille, France) |
| Dennis, James W. | (Mount Sinai Hospital, Canada) |
| Endo, Tamao | (Tokyo Metropolitan Institute of Gerontology, Japan) |
| Filmus, Jorge | (Sunnybrook and Women's College Health Sciences Centre and University of Toronto, Canada) |
| Fukuda, Minoru | (Burnham Institute for Medical Research, USA) |
| Furukawa, Koichi | (Nagoya University School of Medicine, Japan) |
| Gu, Jianxin | (Fudan University, China) |
| Hart, Gerald W. | (Johns Hopkins University, USA) |
| Hennet, Thierry | (University of Zürich, Switzerland) |
| Henrissat, Bernard | (CNRS and Universities of Marseille, France) |
| Hirabayashi, Jun | (National Institute of Advanced Industrial Science and Technology, Japan) |
| Honke, Koichi | (Kochi Medical School, Japan) |
| Irimura, Tatsuro | (University of Tokyo, Japan) |
| Kadomatsu, Kenji | (Nagoya University, Japan) |
| Kannagi, Reiji | (Aichi Cancer Center, Japan) |
| Khoo, Kay-Hooi | (Institute of Biological Chemistry, Academia Sinica, Taiwan) |
| Kim, Cheorl-Ho | (Sungkyungkwan University, Korea) |
| Leffler, Hakon | (Lund University, Sweden) |
| Lennarz, William J. | (Stony Brook University, USA) |
| Marth, Jamey D. | (Howard Hughes Medical Institute, USA) |
| Miyoshi, Eiji | (Osaka University Graduate School Medicine, Japan) |
| Mormann, Michael | (University of Muenster, Germany) |
| Nishihara, Shoko | (Soka University, Japan) |
| Okajima, Tetsuya | (Nagoya University, Japan) |
| Oriol, Rafael | (INSERM U602, France) |
| Paulson, James | (The Scripps Research Institute, USA) |
| Pierce, Michael | (University of Georgia, USA) |
| Ramakrishnan, Boopathy | (National Institutes of Health, USA ) |
| Rudd, Pauline | (The University of Oxford, UK) |
| Saitou, Naruya | (National Institute of Genetics, Japan) |
| Stanley, Pamela | (Albert Einstein College Medicine, USA) |
| Sugahara, Kazuyuki | (Kobe Parmaceutical University, Japan) |
| Suzuki, Akemi | (RIKEN Frontier Research System, Japan) |
| Taniguchi, Naoyuki | (Osaka University Graduate School Medicine, Japan) |
| Wakatsuki, Soichi | (High Energy Accelerator Research Organization, Japan) |
| Wakarchuk, Warren | (National Research Council Canada, Canada) |
| Watanabe, Hideto | (Aichi Medical University, Japan) |
| Wilson, Iain | (University of Natural Resources and Applied Life Sciences, Austria) |
| Yamashita, Katsuko | (Tokyo Institute of Technology, Japan) |
